HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PR40A (O75400)
Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6)
Gene: PRPF40A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35987950
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 957
+	Hs
		226436 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DESP_HUMAN (419-952): 2.38e-60: 227: 12.98
+	Hs
		228398 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CFA57_HUMAN (431-952): 5.61e-49: 191: 14.60
+	Hs
		154708 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TCRG1_HUMAN (6-820): 7.38e-41: 165: 16.47
+	Hs
		226797 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05
+	Hs
		228646 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WWP1_HUMAN (22-297): 5.32e-15: 81.7: 13.88
+	Hs
		227833 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR87_HUMAN (184-936): 1.19e-14: 81.1: 11.97
+	Hs
		226680 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH10_HUMAN (432-957): 1.68e-14: 80.8: 9.98
+	Hs
		125029 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WWP2_HUMAN (4-227): 1.27e-13: 77.3: 12.86
+	Hs
		226691 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH11_HUMAN (528-957): 1.19e-11: 71.1: 10.42
+	Hs
		226679 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH9_HUMAN (528-957): 1.03e-10: 68.1: 11.11
+	Sc
		477458 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		URN1_YEAST (186-646): 2.61e-58: 209: 12.87
+	Hs
		154883 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		TCRG1_HUMAN (6-820): 7.38e-41: 165: 16.47
+	Hs
		808895 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05
+	Hs
		475140 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		ITCH_HUMAN (4-297): 3.34e-18: 92.1: 13.95
+	Rn
		94376 HOIL1_RAT (12-448): 8.73e-66: 221: 17.05		F1M9G7_RAT (2-318): 2.27e-09: 63.7: 9.01
+	Hs
		125112 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		WWP2_HUMAN (4-227): 1.27e-13: 77.3: 12.86
+	Hs
		476205 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ITCH_HUMAN (4-297): 3.34e-18: 92.1: 13.95
+	Hs
		476350 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WWP1_HUMAN (22-297): 5.32e-15: 81.7: 13.88
+	Hs
		125113 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WWP2_HUMAN (4-227): 1.27e-13: 77.3: 12.86
+	Hs
		475417 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MYH9_HUMAN (528-957): 1.03e-10: 68.1: 11.11