HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSIP1 (O75475)
PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)
Gene: PSIP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006979 - response to oxidative stress GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 530
+	Hs
		226933 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MSH6_HUMAN (4-317): 4.4e-58: 211: 15.64
+	Hs
		226919 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HDGF_HUMAN (3-225): 5.03e-24: 102: 38.94
+	Hs
		227905 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HDGR2_HUMAN (1-521): 2.98e-21: 99.5: 20.73
+	Hs
		228115 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		THOC2_HUMAN (106-366): 2.25e-09: 62.4: 14.59
+	Hs
		1115541 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		GLYR1_HUMAN (4-215): 5.73e-35: 139: 20.27
+	Hs
		265948 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSIP1_HUMAN (1-530): 1.2e-79: 260: 100.00