HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1239
+	Hs
		226582 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23
+	Hs
		148181 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33
+	Hs
		227863 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98
+	Hs
		227330 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AAPK1_HUMAN (8-555): 9.95e-123: 392: 16.85
+	Hs
		226637 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82
+	Hs
		227317 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK4_HUMAN (4-517): 8.55e-119: 379: 31.92
+	Hs
		226028 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ROCK2_HUMAN (15-536): 8.84e-107: 369: 22.02
+	Hs
		229162 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52
+	Hs
		228945 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK26_HUMAN (16-414): 6.13e-111: 355: 34.05
+	Sc
		477151 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		KCC4_YEAST (22-923): 2.08e-131: 430: 16.02
+	Hs
		682055 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98
+	Hs
		474935 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82
+	Hs
		475012 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		STK4_HUMAN (4-517): 8.55e-119: 379: 31.92
+	At
		1091642 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPKB_ARATH (3-466): 3.71e-127: 402: 16.49
+	At
		1091676 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPK3_ARATH (16-476): 2.67e-125: 398: 18.91
+	Hs
		475390 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (24-427): 9.81e-118: 377: 21.46