Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TFR1 (P02786)
Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]
Gene: TFRC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.56 0.60 0.584

The method score is based on:

Property Details
Experiments 35509820, 35256949
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0010628 - positive regulation of gene expression
GO:0010637 - negative regulation of mitochondrial fusion
GO:0019901 - protein kinase binding
GO:0030544 - Hsp70 protein binding
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
and 2 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 465
Hs

1 760
+ Sc
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024