HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006979 - response to oxidative stress
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 644
+	Hs
		226262 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44
+	Hs
		226313 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K2C7_HUMAN (138-505): 3.95e-137: 410: 60.33
+	Hs
		226160 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K2C75_HUMAN (1-579): 4.51e-88: 286: 53.89
+	Hs
		226397 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32
+	Hs
		226231 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K2C6B_HUMAN (2-512): 5.16e-79: 263: 62.82
+	Hs
		227741 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K2C79_HUMAN (28-570): 6.02e-78: 259: 56.15
+	Hs
		312447 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44
+	Hs
		227198 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K22O_HUMAN (1-508): 2.87e-69: 239: 60.00
+	Hs
		312440 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		K2C1_HUMAN (1-511): 2.63e-77: 260: 100.00
+	Hs
		312606 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		K2C72_HUMAN (90-496): 1.88e-73: 247: 61.92
+	Hs
		475775 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		K2C72_HUMAN (90-496): 1.88e-73: 247: 61.92