HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ENOA (P06733)
Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein)
Gene: ENO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25959826, 32929329, 35509820, 35256949
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 434
+	Hs
		226407 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ENOB_HUMAN (1-434): 0: 747: 83.41
+	Sc
		342624 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		ENO1_YEAST (1-430): 0: 672: 63.51
+	Sc
		342828 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		ENO2_YEAST (1-430): 0: 636: 62.59
+	At
		636795 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ENO2_ARATH (2-432): 0: 688: 71.72