Protein: PACN2
Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)

Gene: PACN2, PACSIN2
Organism: Homo sapiens
Interactions: 155
UniProt ID: Q9UNF0

Gene Ontology (top 5):
GO:0002042 - cell migration involved in sprouting angiogenesis
GO:0005543 - phospholipid binding
GO:0005737 - cytoplasm
GO:0005768 - endosome
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1417662

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

11

15

Small-scale

0.981

High

1461205

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

8

16

Small-scale

0.971

High

1462293

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

7

17

Small-scale

0.966

High

1453800

RAI14
Ankycorbin

3

10

High-throughput

0.871

High

1461574

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

2

6

Small-scale

0.768

High

271189

COBL
Protein cordon-bleu

6

6

High-throughput

0.736

High

1200471

COBL1
Cordon-bleu protein-like 1

4

13

High-throughput

0.699

High

1250804

MPRIP
Myosin phosphatase Rho-interacting protein

4

11

High-throughput

0.699

High

171350

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

5

High-throughput

0.691

High

869529

TNFL6
Tumor necrosis factor ligand superfamily member 6

3

7

Small-scale

0.675

High

1353775

WIPF2
WAS/WASL-interacting protein family member 2

3

5

High-throughput

0.667

High

133698

WASL
Actin nucleation-promoting factor WASL

3

20

Small-scale

0.658

High

1451563

THG1
Probable tRNA(His) guanylyltransferase

3

0

High-throughput

0.638

High

894248

MEOX2
Homeobox protein MOX-2

2

4

High-throughput

0.633

High

1431723

TARA
TRIO and F-actin-binding protein

2

9

High-throughput

0.628

High

243289

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.618

High

364024

EGFR
Epidermal growth factor receptor

1

16

High-throughput

0.618

High

541755

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

648741

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

710917

EPHB2
Ephrin type-B receptor 2

1

10

High-throughput

0.618

High

761310

RYK
Tyrosine-protein kinase RYK

1

18

High-throughput

0.618

High

931915

EPHA5
Ephrin type-A receptor 5

1

14

High-throughput

0.618

High

932155

EPHA4
Ephrin type-A receptor 4

1

10

High-throughput

0.618

High

1147464

EPHA7
Ephrin type-A receptor 7

1

9

High-throughput

0.618

High

1157111

NTRK3
NT-3 growth factor receptor

1

17

High-throughput

0.618

High

1159556

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.618

High

1325149

MILK1
MICAL-like protein 1

2

4

Small-scale

0.611

High

601498

RHOQ
Rho-related GTP-binding protein RhoQ

2

20

High-throughput

0.601

High

896932

DYN2
Dynamin-2

2

20

Small-scale

0.601

High

376095

RASK
GTPase KRas

2

12

High-throughput

0.584

High

540752

LAMP1
Lysosome-associated membrane glycoprotein 1

2

3

High-throughput

0.584

High

1446621

RIC8A
Chaperone Ric-8A

2

0

High-throughput

0.580

High

928591

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.573

High

962634

RHOA
Transforming protein RhoA

2

20

High-throughput

0.571

High

1462295

3BP1
SH3 domain-binding protein 1

2

11

High-throughput

0.571

High

1434397

EHD1
EH domain-containing protein 1

1

14

Small-scale

0.561

High

1448401

PICK1
PRKCA-binding protein

1

2

Small-scale

0.561

High

192400

GSC2
Homeobox protein goosecoid-2

2

6

High-throughput

0.553

High

1419206

PBX4
Pre-B-cell leukemia transcription factor 4

2

1

High-throughput

0.553

High

1452481

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.552

High

530580

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.536

High

543551

VDR
Vitamin D3 receptor

1

2

High-throughput

0.536

High

834378

GARS
Glycine--tRNA ligase

1

2

High-throughput

0.536

High

993383

ACTG
Actin, cytoplasmic 2

1

1

High-throughput

0.536

High

1179040

S35G1
Solute carrier family 35 member G1

1

2

High-throughput

0.536

High

1340478

DDX55
ATP-dependent RNA helicase DDX55

1

2

High-throughput

0.536

High

1347896

RIN3
Ras and Rab interactor 3

1

8

High-throughput

0.536

High

1412168

ERP44
Endoplasmic reticulum resident protein 44

1

1

High-throughput

0.536

High

1413333

DIDO1
Death-inducer obliterator 1

1

8

High-throughput

0.536

High

1437531

CLXN
Calaxin

1

2

High-throughput

0.536

High

1450074

ABCF3
ATP-binding cassette sub-family F member 3

1

1

High-throughput

0.536

High

1453533

SPN90
NCK-interacting protein with SH3 domain

1

4

High-throughput

0.536

High

1459685

SWP70
Switch-associated protein 70

1

17

High-throughput

0.536

High

106854

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

260738

RAMP1
Receptor activity-modifying protein 1

1

0

High-throughput

0.513

High

335523

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.513

High

549359

SRF
Serum response factor

1

0

High-throughput

0.513

High

709028

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.513

High

892983

ENTP1
Ectonucleoside triphosphate diphosphohydrolase 1

1

0

High-throughput

0.513

High

947898

T2R31
Taste receptor type 2 member 31

1

0

High-throughput

0.513

High

1154478

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.513

High

1178462

CL16A
Protein CLEC16A

1

0

High-throughput

0.513

High

1280997

PXK
PX domain-containing protein kinase-like protein

1

0

High-throughput

0.513

High

1291990

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

High-throughput

0.513

High

1418786

HELZ2
3'-5' exoribonuclease HELZ2

1

0

High-throughput

0.513

High

1450186

POTE1
Protection of telomeres protein 1

1

2

High-throughput

0.504

High

215960

SYNJ1
Synaptojanin-1

1

9

Small-scale

0.501

High

1050724

DYN1
Dynamin-1

1

20

Small-scale

0.501

High

1137587

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.489

High

1314278

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

1

High-throughput

0.489

High

1335962

ZBT44
Zinc finger and BTB domain-containing protein 44

1

3

High-throughput

0.489

High

1398313

RN145
RING finger protein 145

1

3

High-throughput

0.489

High

1398687

ZN75A
Zinc finger protein 75A

1

1

High-throughput

0.489

High

407822

SHBG
Sex hormone-binding globulin

1

1

Small-scale

0.481

High

1040940

MECOM
Histone-lysine N-methyltransferase MECOM

1

2

High-throughput

0.481

High

126873

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

161107

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

19

Small-scale

0.479

High

170431

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

189926

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

218959

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

219567

WIPF1
WAS/WASL-interacting protein family member 1

1

19

Small-scale

0.479

High

341170

DIRA3
GTP-binding protein Di-Ras3

1

3

High-throughput

0.479

High

374281

RASN
GTPase NRas

1

12

High-throughput

0.479

High

417849

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

538115

HSP7C
Heat shock cognate 71 kDa protein

1

2

Small-scale

0.479

High

556424

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

583024

EZRI
Ezrin

1

1

High-throughput

0.479

High

630665

RAB3B
Ras-related protein Rab-3B

1

2

High-throughput

0.479

High

631561

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.479

High

643136

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.479

High

693133

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

838516

GRIA2
Glutamate receptor 2

1

5

Small-scale

0.479

High

838539

GRIA3
Glutamate receptor 3

1

5

Small-scale

0.479

High

842672

WASP
Actin nucleation-promoting factor WAS

1

20

Small-scale

0.479

High

845860

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.479

High

884614

SYCC
Cysteine--tRNA ligase, cytoplasmic

1

4

Small-scale

0.479

High

891885

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

910252

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

953758

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955755

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

962860

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

975320

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

976663

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

978404

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

988825

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1008462

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

19

Small-scale

0.479

High

1015904

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1031597

IFM3
Interferon-induced transmembrane protein 3

1

2

High-throughput

0.479

High

1033311

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

1060001

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

6

Small-scale

0.479

High

1110891

IRF5
Interferon regulatory factor 5

1

1

High-throughput

0.479

High

1145172

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.479

High

1151930

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1159905

OCLN
Occludin

1

1

High-throughput

0.479

High

1198168

SBK1
Serine/threonine-protein kinase SBK1

1

5

Small-scale

0.479

High

1233576

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1256089

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1271052

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1279429

AB1IP
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

1

10

Small-scale

0.479

High

1340529

DNJB8
DnaJ homolog subfamily B member 8

1

1

High-throughput

0.479

High

1362016

RFFL
E3 ubiquitin-protein ligase rififylin

1

2

Small-scale

0.479

High

1366912

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1382004

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.479

High

1390225

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

4

Small-scale

0.479

High

1396658

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

1433004

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.479

High

1433578

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1438244

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1449556

SMC4
Structural maintenance of chromosomes protein 4

1

3

High-throughput

0.479

High

1459309

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1232641

Q6FHY5
MEOX2 protein

1

4

High-throughput

0.470

High

1384050

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.460

High

226261

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

1041369

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1364687

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1418520

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

935289

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

1227706

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.445

High

1235026

PKHA7
Pleckstrin homology domain-containing family A member 7

1

9

High-throughput

0.445

High

1449920

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

1462294

GAB2
GRB2-associated-binding protein 2

1

9

High-throughput

0.445

High

937969

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.437

High

1287472

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

4

Small-scale

0.437

High

1293205

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

369219

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

404957

PRIO
Major prion protein

1

0

High-throughput

0.426

High

330372

VENTX
Homeobox protein VENTX

1

8

High-throughput

0.407

High

192518

INSI1
Insulin-induced gene 1 protein

1

0

High-throughput

0.279

Low

638604

ZNF10
Zinc finger protein 10

1

0

High-throughput

0.279

Low

1059134

PIGF
GPI ethanolamine phosphate transferase, stabilizing subunit

1

0

High-throughput

0.279

Low

1214144

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.279

Low

1256471

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.279

Low

1308378

CCD71
Coiled-coil domain-containing protein 71

1

0

High-throughput

0.279

Low

1453377

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025