HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NFL (P07196)
Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)
Gene: NEFL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043274 - phospholipase binding GO:0044877 - protein-containing complex binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 543
+	Hs
		227198 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K22O_HUMAN (69-414): 1.55e-134: 406: 32.09
+	Hs
		226262 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K2C8_HUMAN (69-431): 4.2e-132: 394: 36.44
+	Hs
		227571 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AINX_HUMAN (66-401): 1.66e-91: 290: 58.11
+	Hs
		226310 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		VIME_HUMAN (34-402): 6.74e-84: 270: 49.59
+	Hs
		226160 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K2C75_HUMAN (2-411): 2.04e-77: 255: 28.40
+	Hs
		227741 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K2C79_HUMAN (3-413): 2.08e-75: 250: 25.48
+	Hs
		226277 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NFM_HUMAN (82-409): 4.21e-72: 249: 54.71
+	Hs
		226459 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DESM_HUMAN (69-402): 4.31e-72: 239: 53.89
+	Hs
		226410 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GFAP_HUMAN (66-401): 1.36e-70: 234: 48.21
+	Hs
		226397 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K2C5_HUMAN (56-403): 3.13e-64: 221: 31.62
+	Hs
		226231 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		K2C6B_HUMAN (56-419): 8.8e-64: 220: 30.79
+	Hs
		312447 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		K2C8_HUMAN (69-431): 4.2e-132: 394: 36.44
+	Hs
		782017 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		PERI_HUMAN (9-401): 1.77e-69: 232: 48.12
+	Hs
		312606 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		K2C72_HUMAN (5-403): 2.45e-71: 238: 28.86
+	Hs
		443281 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		VIME_HUMAN (34-402): 6.74e-84: 270: 49.59
+	Hs
		475775 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		K2C72_HUMAN (5-403): 2.45e-71: 238: 28.86