HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25959826, 35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0019899 - enzyme binding GO:0034976 - response to endoplasmic reticulum stress
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 508
+	Hs
		226618 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57
+	Hs
		226398 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22
+	Hs
		228519 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ERP44_HUMAN (363-494): 1.8e-23: 104: 17.39
+	Hs
		227992 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38
+	Hs
		227501 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PDIA6_HUMAN (372-462): 5.71e-09: 60.1: 36.26
+	Hs
		312626 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38
+	At
		1092003 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PDI14_ARATH (12-145): 1.01e-14: 78.7: 27.94