HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: C1TC (P11586)
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]
Gene: MTHFD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25959826, 32929329, 35509820, 35256949
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 935
+	Hs
		227812 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		C1TM_HUMAN (11-935): 0: 1408: 61.41
+	Hs
		475286 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		C1TC_HUMAN (1-935): 0: 1571: 100.00
+	Hs
		226408 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MTDC_HUMAN (4-299): 5.01e-122: 376: 38.24
+	At
		1092465 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9ZUP9_ARATH (851-924): 8.1e-42: 149: 72.97