Protein: ATP4A
Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)

Gene: ATP4A
Organism: Homo sapiens
Interactions: 102
UniProt ID: P20648

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0005391 - P-type sodium:potassium-exchanging transporter activity
GO:0005524 - ATP binding
GO:0005615 - extracellular space
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

420765

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

2

16

Small-scale

0.789

High

565552

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

13

High-throughput

0.691

High

240180

KLK8
Kallikrein-8

3

6

High-throughput

0.667

High

124231

HAX1
HCLS1-associated protein X-1

3

0

High-throughput

0.638

High

633924

DGUOK
Deoxyguanosine kinase, mitochondrial

3

0

High-throughput

0.638

High

420355

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

12

Small-scale

0.618

High

633879

ATP4A
Potassium-transporting ATPase alpha chain 1

1

13

Small-scale

0.618

High

633894

ATP4B
Potassium-transporting ATPase subunit beta

1

16

Small-scale

0.618

High

633939

KTU
Protein kintoun

3

1

High-throughput

0.609

High

538302

LIPC
Hepatic triacylglycerol lipase

2

0

High-throughput

0.602

High

450196

LIPF
Gastric triacylglycerol lipase

1

0

Small-scale

0.517

High

450212

HYEP
Epoxide hydrolase 1

1

0

Small-scale

0.517

High

633896

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.513

High

633889

CLK1
Dual specificity protein kinase CLK1

1

5

High-throughput

0.501

High

189418

STX7
Syntaxin-7

1

5

Small-scale

0.479

High

254052

CTND1
Catenin delta-1

1

3

Small-scale

0.479

High

297143

PRAF3
PRA1 family protein 3

1

4

Small-scale

0.479

High

299933

CBPD
Carboxypeptidase D

1

1

Small-scale

0.479

High

328629

VAMP5
Vesicle-associated membrane protein 5

1

12

Small-scale

0.479

High

342744

HERC2
E3 ubiquitin-protein ligase HERC2

1

2

High-throughput

0.479

High

352955

AGR2
Anterior gradient protein 2 homolog

1

3

Small-scale

0.479

High

388836

APOH
Beta-2-glycoprotein 1

1

1

Small-scale

0.479

High

402851

ANXA1
Annexin A1

1

4

Small-scale

0.479

High

418587

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

6

Small-scale

0.479

High

456605

ANXA2
Annexin A2

1

4

Small-scale

0.479

High

466000

ANXA6
Annexin A6

1

4

Small-scale

0.479

High

627920

ANXA7
Annexin A7

1

4

Small-scale

0.479

High

633881

MRC1
Macrophage mannose receptor 1

1

2

Small-scale

0.479

High

633882

VAMP1
Vesicle-associated membrane protein 1

1

15

Small-scale

0.479

High

633885

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

3

Small-scale

0.479

High

633886

BASI
Basigin

1

4

Small-scale

0.479

High

633887

VATA
V-type proton ATPase catalytic subunit A

1

2

Small-scale

0.479

High

633890

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

6

Small-scale

0.479

High

633891

ANX11
Annexin A11

1

4

Small-scale

0.479

High

633892

RAB5C
Ras-related protein Rab-5C

1

9

Small-scale

0.479

High

633893

RAB7A
Ras-related protein Rab-7a

1

11

High-throughput

0.479

High

633895

BAP31
B-cell receptor-associated protein 31

1

2

Small-scale

0.479

High

633897

KCNQ1
Potassium voltage-gated channel subfamily KQT member 1

1

7

Small-scale

0.479

High

633899

S12A2
Solute carrier family 12 member 2

1

3

Small-scale

0.479

High

633900

RAB25
Ras-related protein Rab-25

1

6

Small-scale

0.479

High

633901

FAM3B
Protein FAM3B

1

2

Small-scale

0.479

High

633903

RAB10
Ras-related protein Rab-10

1

5

Small-scale

0.479

High

633906

VAMP2
Vesicle-associated membrane protein 2

1

13

Small-scale

0.479

High

633907

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

6

Small-scale

0.479

High

633908

CLH1
Clathrin heavy chain 1

1

2

Small-scale

0.479

High

633909

CAV1
Caveolin-1

1

4

Small-scale

0.479

High

633910

LG3BP
Galectin-3-binding protein

1

3

Small-scale

0.479

High

633912

LMAN2
Vesicular integral-membrane protein VIP36

1

2

Small-scale

0.479

High

633913

STX3
Syntaxin-3

1

5

Small-scale

0.479

High

633915

SCRB2
Lysosome membrane protein 2

1

1

Small-scale

0.479

High

633919

VAMP3
Vesicle-associated membrane protein 3

1

13

Small-scale

0.479

High

633922

CAH9
Carbonic anhydrase 9

1

2

Small-scale

0.479

High

633927

S26A9
Solute carrier family 26 member 9

1

2

Small-scale

0.479

High

633928

C163A
Scavenger receptor cysteine-rich type 1 protein M130

1

2

Small-scale

0.479

High

633932

FAM3C
Protein FAM3C

1

2

Small-scale

0.479

High

633936

VAMP8
Vesicle-associated membrane protein 8

1

14

Small-scale

0.479

High

633937

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

10

High-throughput

0.479

High

633943

TFR2
Transferrin receptor protein 2

1

1

Small-scale

0.479

High

387232

APOA1
Apolipoprotein A-I

1

0

Small-scale

0.458

High

628384

PEPC
Gastricsin

1

0

Small-scale

0.458

High

633835

MPRD
Cation-dependent mannose-6-phosphate receptor

1

0

Small-scale

0.458

High

633884

IF
Cobalamin binding intrinsic factor

1

0

Small-scale

0.458

High

633902

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

0

Small-scale

0.458

High

633911

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

Small-scale

0.458

High

633921

SYPL1
Synaptophysin-like protein 1

1

0

Small-scale

0.458

High

633923

AOC3
Amine oxidase [copper-containing] 3

1

0

Small-scale

0.458

High

633929

TPRA1
Transmembrane protein adipocyte-associated 1

1

0

Small-scale

0.458

High

633933

MAL2
Protein MAL2

1

0

Small-scale

0.458

High

633945

KCNE2
Potassium voltage-gated channel subfamily E member 2

1

0

Small-scale

0.458

High

126992

APBB1
Amyloid beta precursor protein binding family B member 1

1

3

High-throughput

0.445

High

633880

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.445

High

319389

UFL1
E3 UFM1-protein ligase 1

1

3

Small-scale

0.439

High

122590

UBXN8
UBX domain-containing protein 8

1

7

High-throughput

0.437

High

165528

SCAM3
Secretory carrier-associated membrane protein 3

1

3

Small-scale

0.437

High

178899

SCAM2
Secretory carrier-associated membrane protein 2

1

3

Small-scale

0.437

High

226397

SNG2
Synaptogyrin-2

1

1

Small-scale

0.437

High

231102

AIRE
Autoimmune regulator

1

4

Small-scale

0.437

High

280123

SC22B
Vesicle-trafficking protein SEC22b

1

4

Small-scale

0.437

High

324520

HEXI1
Protein HEXIM1

1

4

High-throughput

0.437

High

610981

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

8

Small-scale

0.437

High

633883

3BHS2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

1

4

Small-scale

0.437

High

633898

SNAA
Alpha-soluble NSF attachment protein

1

1

Small-scale

0.437

High

633904

RB11A
Ras-related protein Rab-11A

1

7

Small-scale

0.437

High

633905

RAB1A
Ras-related protein Rab-1A

1

4

Small-scale

0.437

High

633914

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.437

High

633917

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

4

High-throughput

0.437

High

633918

TNIP1
TNFAIP3-interacting protein 1

1

8

High-throughput

0.437

High

633920

RB11B
Ras-related protein Rab-11B

1

8

Small-scale

0.437

High

633926

TM41B
Transmembrane protein 41B

1

2

High-throughput

0.437

High

633930

STX12
Syntaxin-12

1

5

Small-scale

0.437

High

633934

FAF2
FAS-associated factor 2

1

7

High-throughput

0.437

High

633935

VAT1
Synaptic vesicle membrane protein VAT-1 homolog

1

2

Small-scale

0.437

High

633941

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

633925

BOREA
Borealin

3

0

High-throughput

0.347

High

633931

ERO1B
ERO1-like protein beta

3

0

High-throughput

0.347

High

633940

ARMC1
Armadillo repeat-containing protein 1

3

0

High-throughput

0.347

High

633942

NUFP1
FMR1-interacting protein NUFIP1

3

0

High-throughput

0.347

High

633944

RRP7A
Ribosomal RNA-processing protein 7 homolog A

3

0

High-throughput

0.347

High

633888

LSS
Lanosterol synthase

1

0

Small-scale

0.249

Low

633916

GANAB
Neutral alpha-glucosidase AB

1

0

Small-scale

0.249

Low

633938

ANLN
Anillin

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025