HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

Property	Details
Experiments	35509820, 35987950, 35256949, 20810900, 23503661
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1901800 - positive regulation of proteasomal protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 439
+	Hs
		227060 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60
+	Hs
		227061 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39
+	Hs
		226773 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59
+	Hs
		226980 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TERA_HUMAN (162-434): 9.21e-77: 256: 35.17
+	Hs
		228067 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AFG2A_HUMAN (182-435): 3.65e-68: 234: 35.32
+	Sc
		477199 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PRS6A_YEAST (20-439): 2.06e-117: 351: 68.08
+	Ce
		183868 Q9XUS3_CAEEL (6-464): 2.19e-70: 230: 25.44		PRS4_CAEEL (44-432): 3.88e-106: 323: 44.28
+	Hs
		474950 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59
+	Hs
		475318 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00
+	Hs
		475569 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60
+	Sc
		477313 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PRS4_YEAST (122-431): 4.87e-102: 312: 50.65
+	Hs
		875476 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		TERA_HUMAN (162-434): 9.21e-77: 256: 35.17
+	Hs
		475459 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59
+	Hs
		312526 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		TERA_HUMAN (162-434): 9.21e-77: 256: 35.17
+	Sc
		477159 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		CDC48_YEAST (144-419): 9.98e-80: 265: 37.32
+	Hs
		474971 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		TERA_HUMAN (162-434): 9.21e-77: 256: 35.17
+	Hs
		875357 RN19A_HUMAN (236-452): 6.6e-31: 128: 21.62		TERA_HUMAN (162-434): 9.21e-77: 256: 35.17
+	Mm
		841457 RN19A_MOUSE (236-452): 2.59e-30: 126: 21.62		TERA_MOUSE (162-434): 9.21e-77: 256: 35.17
+	Hs
		87546 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		C9JUP7_HUMAN (162-434): 1.61e-77: 257: 35.17
+	Hs
		475529 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TERA_HUMAN (162-434): 9.21e-77: 256: 35.17