HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	32929329, 35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 808
+	Hs
		226857 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MCM2_HUMAN (10-721): 0: 707: 30.62
+	Hs
		227454 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MCM6_HUMAN (2-800): 0: 688: 26.50
+	Hs
		226659 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MCM5_HUMAN (9-713): 0: 685: 28.92
+	Hs
		226658 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MCM4_HUMAN (9-739): 0: 661: 28.03
+	Hs
		226660 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MCM7_HUMAN (10-669): 0: 650: 31.62
+	Hs
		474959 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		MCM2_HUMAN (10-721): 0: 707: 30.62
+	Hs
		474939 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		MCM5_HUMAN (9-713): 0: 685: 28.92
+	Hs
		474940 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		MCM7_HUMAN (10-669): 0: 650: 31.62
+	Hs
		475488 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MCM2_HUMAN (10-721): 0: 707: 30.62
+	Hs
		475399 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MCM5_HUMAN (9-713): 0: 685: 28.92