Protein: TLX1
T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)

Gene: TLX1
Organism: Homo sapiens
Interactions: 174
UniProt ID: P31314

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

137123

MEIS1
Homeobox protein Meis1

2

20

Small-scale

0.783

High

163413

MEIS2
Homeobox protein Meis2

2

20

Small-scale

0.783

High

725216

PBX2
Pre-B-cell leukemia transcription factor 2

2

20

Small-scale

0.757

High

725215

PBX1
Pre-B-cell leukemia transcription factor 1

1

20

Small-scale

0.653

High

725212

TLX1
T-cell leukemia homeobox protein 1

1

17

Small-scale

0.647

High

725213

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

8

Small-scale

0.629

High

725244

TLE1
Transducin-like enhancer protein 1

2

20

Small-scale

0.624

High

604791

HXB9
Homeobox protein Hox-B9

1

17

High-throughput

0.618

High

725214

CUX1
Homeobox protein cut-like 1

1

20

High-throughput

0.618

High

725221

MNX1
Motor neuron and pancreas homeobox protein 1

1

18

High-throughput

0.618

High

725242

TFAP4
Transcription factor AP-4

1

1

High-throughput

0.618

High

725243

SATB1
DNA-binding protein SATB1

1

8

High-throughput

0.618

High

725255

MEF2D
Myocyte-specific enhancer factor 2D

1

1

High-throughput

0.618

High

725258

ZFHX3
Zinc finger homeobox protein 3

1

12

High-throughput

0.618

High

725280

ZFHX4
Zinc finger homeobox protein 4

1

17

High-throughput

0.618

High

725335

SIX4
Homeobox protein SIX4

1

20

High-throughput

0.618

High

725340

SATB2
DNA-binding protein SATB2

1

8

High-throughput

0.618

High

725217

PBX3
Pre-B-cell leukemia transcription factor 3

1

20

Small-scale

0.590

High

725229

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

7

Small-scale

0.573

High

725232

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

7

Small-scale

0.573

High

625213

CSK22
Casein kinase II subunit alpha'

1

18

High-throughput

0.536

High

725247

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.536

High

445500

IF4E
Eukaryotic translation initiation factor 4E

1

5

Small-scale

0.501

High

135073

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

6

High-throughput

0.500

High

430996

LA
Lupus La protein

1

2

High-throughput

0.500

High

552511

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.500

High

557887

XRCC6
X-ray repair cross-complementing protein 6

1

12

High-throughput

0.500

High

559231

XRCC5
X-ray repair cross-complementing protein 5

1

12

High-throughput

0.500

High

694717

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.500

High

725220

DNLI3
DNA ligase 3

1

3

High-throughput

0.500

High

725227

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.500

High

725233

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.500

High

725235

CSK21
Casein kinase II subunit alpha

1

11

High-throughput

0.500

High

725241

TFAM
Transcription factor A, mitochondrial

1

20

High-throughput

0.500

High

725271

UBN2
Ubinuclein-2

1

20

High-throughput

0.500

High

725274

DHX30
ATP-dependent RNA helicase DHX30

1

4

High-throughput

0.500

High

725318

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.500

High

725329

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

6

High-throughput

0.500

High

476570

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.479

High

725225

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.479

High

725230

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.479

High

725231

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.479

High

725265

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.479

High

142858

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

154633

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

161417

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

174315

ZN609
Zinc finger protein 609

1

19

High-throughput

0.479

High

177440

ZN536
Zinc finger protein 536

1

12

High-throughput

0.479

High

194515

KDM6A
Lysine-specific demethylase 6A

1

7

High-throughput

0.479

High

245593

ZEB2
Zinc finger E-box-binding homeobox 2

1

11

High-throughput

0.479

High

261372

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

14

High-throughput

0.479

High

277153

ZN217
Zinc finger protein 217

1

7

High-throughput

0.479

High

278247

NCOR1
Nuclear receptor corepressor 1

1

20

High-throughput

0.479

High

297467

PIAS1
E3 SUMO-protein ligase PIAS1

1

5

High-throughput

0.479

High

341528

EYA4
Protein phosphatase EYA4

1

16

High-throughput

0.479

High

344875

WIZ
Protein Wiz

1

10

High-throughput

0.479

High

473815

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

505522

ATX1L
Ataxin-1-like

1

5

High-throughput

0.479

High

559730

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

20

High-throughput

0.479

High

577410

ETS1
Protein C-ets-1

1

19

Small-scale

0.479

High

586230

ZEP1
Zinc finger protein 40

1

9

High-throughput

0.479

High

725223

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

20

High-throughput

0.479

High

725224

ATN1
Atrophin-1

1

20

High-throughput

0.479

High

725236

SSBP2
Single-stranded DNA-binding protein 2

1

8

High-throughput

0.479

High

725240

FOXK1
Forkhead box protein K1

1

20

High-throughput

0.479

High

725245

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

725246

TLE4
Transducin-like enhancer protein 4

1

20

High-throughput

0.479

High

725248

RING1
E3 ubiquitin-protein ligase RING1

1

18

High-throughput

0.479

High

725249

TLE5
TLE family member 5

1

20

High-throughput

0.479

High

725250

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

725251

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.479

High

725252

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

725253

FOXC1
Forkhead box protein C1

1

20

High-throughput

0.479

High

725256

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

1

Small-scale

0.479

High

725257

NCOA2
Nuclear receptor coactivator 2

1

17

High-throughput

0.479

High

725261

ZN260
Zinc finger protein 260

1

3

High-throughput

0.479

High

725262

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

725263

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

High-throughput

0.479

High

725267

NIPBL
Nipped-B-like protein

1

11

High-throughput

0.479

High

725269

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

20

High-throughput

0.479

High

725270

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

725272

PAXI1
PAX-interacting protein 1

1

16

High-throughput

0.479

High

725275

POGZ
Pogo transposable element with ZNF domain

1

10

High-throughput

0.479

High

725276

I2BP2
Interferon regulatory factor 2-binding protein 2

1

16

High-throughput

0.479

High

725277

PCGF5
Polycomb group RING finger protein 5

1

20

High-throughput

0.479

High

725278

LDB1
LIM domain-binding protein 1

1

8

High-throughput

0.479

High

725279

PB1
Protein polybromo-1

1

17

High-throughput

0.479

High

725281

I2BP1
Interferon regulatory factor 2-binding protein 1

1

1

High-throughput

0.479

High

725282

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

725283

ARI3B
AT-rich interactive domain-containing protein 3B

1

20

High-throughput

0.479

High

725284

HOMEZ
Homeobox and leucine zipper protein Homez

1

20

High-throughput

0.479

High

725285

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

725286

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

725287

KDM2B
Lysine-specific demethylase 2B

1

7

High-throughput

0.479

High

725288

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

2

High-throughput

0.479

High

725289

AUTS2
Autism susceptibility gene 2 protein

1

20

High-throughput

0.479

High

725292

MAML1
Mastermind-like protein 1

1

20

High-throughput

0.479

High

725293

ZN516
Zinc finger protein 516

1

10

High-throughput

0.479

High

725294

RREB1
Ras-responsive element-binding protein 1

1

6

High-throughput

0.479

High

725295

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

725296

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

725297

CBP
CREB-binding protein

1

20

High-throughput

0.479

High

725298

KAT6A
Histone acetyltransferase KAT6A

1

20

High-throughput

0.479

High

725299

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.479

High

725300

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

7

High-throughput

0.479

High

725301

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

8

High-throughput

0.479

High

725302

ZN503
Zinc finger protein 503

1

6

High-throughput

0.479

High

725303

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

3

High-throughput

0.479

High

725304

ZN462
Zinc finger protein 462

1

3

High-throughput

0.479

High

725305

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

20

High-throughput

0.479

High

725306

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

725308

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

725309

EYA3
Protein phosphatase EYA3

1

4

High-throughput

0.479

High

725310

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

725312

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.479

High

725314

SSBP3
Single-stranded DNA-binding protein 3

1

13

High-throughput

0.479

High

725315

SP130
Histone deacetylase complex subunit SAP130

1

15

High-throughput

0.479

High

725316

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

4

High-throughput

0.479

High

725317

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

725319

ZN644
Zinc finger protein 644

1

13

High-throughput

0.479

High

725320

ZN703
Zinc finger protein 703

1

12

High-throughput

0.479

High

725321

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

20

High-throughput

0.479

High

725324

SHCAF
SIN3-HDAC complex-associated factor

1

3

High-throughput

0.479

High

725325

HM20A
High mobility group protein 20A

1

20

High-throughput

0.479

High

725326

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

725327

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.479

High

725328

SALL1
Sal-like protein 1

1

18

High-throughput

0.479

High

725330

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

16

High-throughput

0.479

High

725331

RCOR3
REST corepressor 3

1

20

High-throughput

0.479

High

725332

TCF20
Transcription factor 20

1

20

High-throughput

0.479

High

725333

TRPS1
Zinc finger transcription factor Trps1

1

15

High-throughput

0.479

High

725336

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

725337

ZN608
Zinc finger protein 608

1

9

High-throughput

0.479

High

725338

PRR12
Proline-rich protein 12

1

20

High-throughput

0.479

High

725341

SMC3
Structural maintenance of chromosomes protein 3

1

5

High-throughput

0.479

High

725344

ZN281
Zinc finger protein 281

1

11

High-throughput

0.479

High

725347

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

10

High-throughput

0.479

High

725348

NCOR2
Nuclear receptor corepressor 2

1

20

High-throughput

0.479

High

725350

NCOA3
Nuclear receptor coactivator 3

1

17

High-throughput

0.479

High

725268

LIN54
Protein lin-54 homolog

1

0

High-throughput

0.458

High

725291

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

725313

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

High-throughput

0.458

High

725334

DACH1
Dachshund homolog 1

1

0

High-throughput

0.458

High

229969

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

6

High-throughput

0.457

High

482838

TPM1
Tropomyosin alpha-1 chain

1

3

High-throughput

0.457

High

725222

EMD
Emerin

1

4

High-throughput

0.457

High

725234

TPM4
Tropomyosin alpha-4 chain

1

2

High-throughput

0.457

High

725237

RT22
Small ribosomal subunit protein mS22

1

3

High-throughput

0.457

High

725238

RT09
Small ribosomal subunit protein uS9m

1

2

High-throughput

0.457

High

725264

RRP12
RRP12-like protein

1

3

High-throughput

0.457

High

725290

RT27
Small ribosomal subunit protein mS27

1

2

High-throughput

0.457

High

725339

G3BP2
Ras GTPase-activating protein-binding protein 2

1

1

High-throughput

0.457

High

725342

RT28
Small ribosomal subunit protein bS1m

1

1

High-throughput

0.457

High

725343

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.457

High

725345

RT23
Small ribosomal subunit protein mS23

1

2

High-throughput

0.457

High

725349

RT18B
Small ribosomal subunit protein mS40

1

2

High-throughput

0.457

High

138973

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.437

High

725226

DCAF7
DDB1- and CUL4-associated factor 7

1

11

High-throughput

0.437

High

725254

GSE1
Genetic suppressor element 1

1

2

High-throughput

0.437

High

725260

QSER1
Glutamine and serine-rich protein 1

1

20

High-throughput

0.437

High

725266

ZMYM4
Zinc finger MYM-type protein 4

1

4

High-throughput

0.437

High

725273

ASXL2
Putative Polycomb group protein ASXL2

1

19

High-throughput

0.437

High

725311

PYGO2
Pygopus homolog 2

1

3

High-throughput

0.437

High

725322

FBRS
Probable fibrosin-1

1

8

High-throughput

0.437

High

725323

FBSL
Fibrosin-1-like protein

1

8

High-throughput

0.437

High

725346

PYGO1
Pygopus homolog 1

1

15

High-throughput

0.437

High

725259

CTF1
Cardiotrophin-1

1

0

Small-scale

0.261

Low

256243

RT14
Small ribosomal subunit protein uS14m

1

0

High-throughput

0.261

Low

725218

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.261

Low

725219

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.261

Low

725228

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.261

Low

725307

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.261

Low

725239

RL36A
Large ribosomal subunit protein eL42

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025