HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSA4 (P25789)
Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L)
Gene: PSMA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.690

Property	Details
Experiments	15987638, 35256949, 16714300, 23503661
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 261
+	Hs
		227023 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA6_HUMAN (2-244): 3.23e-92: 273: 31.84
+	Hs
		226564 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA1_HUMAN (4-259): 2.5e-91: 272: 28.57
+	Hs
		156176 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA7_HUMAN (5-238): 2.84e-91: 271: 33.19
+	Hs
		228119 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSMA8_HUMAN (1-238): 2.67e-88: 264: 34.69
+	Hs
		226565 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA2_HUMAN (3-214): 6.04e-42: 145: 38.68
+	Hs
		637475 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PSA1_HUMAN (4-259): 2.5e-91: 272: 28.57
+	Hs
		893742 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		PSA6_HUMAN (2-244): 3.23e-92: 273: 31.84
+	Hs
		637539 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		PSA1_HUMAN (4-259): 2.5e-91: 272: 28.57
+	Hs
		474931 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PSA4_HUMAN (1-237): 2.4e-98: 289: 100.00
+	Sc
		477138 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PSA3_YEAST (2-245): 2.67e-89: 267: 52.03
+	At
		286456 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA4A_ARATH (1-248): 8.93e-98: 288: 58.40
+	Hs
		475547 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA6_HUMAN (2-244): 3.23e-92: 273: 31.84
+	Hs
		475358 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA1_HUMAN (4-259): 2.5e-91: 272: 28.57
+	Hs
		156205 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA7_HUMAN (5-238): 2.84e-91: 271: 33.19
+	At
		286449 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA6A_ARATH (2-244): 4.58e-91: 270: 31.84
+	At
		189234 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA7B_ARATH (3-237): 6.52e-88: 263: 36.02
+	At
		286452 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA6B_ARATH (2-244): 1.42e-86: 259: 30.61
+	Hs
		474930 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PSA2_HUMAN (3-214): 6.04e-42: 145: 38.68
+	At
		188696 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA2A_ARATH (4-241): 6.12e-44: 150: 38.66
+	Hs
		475359 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA2_HUMAN (3-214): 6.04e-42: 145: 38.68