HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: MARCS (P29966)
Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
Gene: MARCKS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007005 - mitochondrion organization GO:0007417 - central nervous system development GO:0034976 - response to endoplasmic reticulum stress
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 332
+	Hs
		228767 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MAGE1_HUMAN (3-326): 4.56e-11: 66: 11.66
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (1-328): 4.66e-10: 63.3: 12.69
+	Hs
		227838 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SRCAP_HUMAN (6-322): 1.54e-09: 61.3: 12.62
+	Hs
		228373 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CHAP1_HUMAN (10-330): 1.59e-09: 61.1: 9.35
+	Hs
		228210 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TITIN_HUMAN (1-308): 6.95e-09: 59.4: 10.71
+	Mm
		88466 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		D3Z656_MOUSE (2-313): 2.54e-09: 60.6: 12.89
+	At
		1092118 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9LIE8_ARATH (2-183): 5.66e-09: 59.4: 13.12