Protein: TLX2
T-cell leukemia homeobox protein 2 (Homeobox protein Hox-11L1) (Neural crest homeobox protein)

Gene: TLX2
Organism: Homo sapiens
Interactions: 140
UniProt ID: O43763

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001707 - mesoderm formation
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

226528

PO6F2
POU domain, class 6, transcription factor 2

2

20

High-throughput

0.783

High

137115

MEIS1
Homeobox protein Meis1

1

20

High-throughput

0.698

High

226511

PO2F1
POU domain, class 2, transcription factor 1

1

20

High-throughput

0.698

High

226506

MYCN
N-myc proto-oncogene protein

1

11

High-throughput

0.618

High

226518

CUX1
Homeobox protein cut-like 1

1

20

High-throughput

0.618

High

226522

MNX1
Motor neuron and pancreas homeobox protein 1

1

19

High-throughput

0.618

High

226536

SATB1
DNA-binding protein SATB1

1

8

High-throughput

0.618

High

226555

ZFHX3
Zinc finger homeobox protein 3

1

12

High-throughput

0.618

High

226619

SATB2
DNA-binding protein SATB2

1

8

High-throughput

0.618

High

226537

TLE1
Transducin-like enhancer protein 1

2

20

High-throughput

0.614

High

226507

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.561

High

226541

1433F
14-3-3 protein eta

1

1

Small-scale

0.561

High

226557

KRA62
Keratin-associated protein 6-2

2

4

High-throughput

0.553

High

167182

IRF6
Interferon regulatory factor 6

1

8

High-throughput

0.541

High

226535

IRF9
Interferon regulatory factor 9

1

8

High-throughput

0.541

High

226577

ZN502
Zinc finger protein 502

1

1

High-throughput

0.541

High

226618

TF2AY
TFIIA-alpha and beta-like factor

1

10

High-throughput

0.541

High

226564

DHX30
ATP-dependent RNA helicase DHX30

1

3

High-throughput

0.536

High

226516

MCM4
DNA replication licensing factor MCM4

1

0

High-throughput

0.518

High

142734

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.515

High

226544

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.515

High

226517

HNF1B
Hepatocyte nuclear factor 1-beta

1

19

High-throughput

0.501

High

226553

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.501

High

165209

PSA7
Proteasome subunit alpha type-7

1

1

High-throughput

0.500

High

226513

PSA3
Proteasome subunit alpha type-3

1

4

High-throughput

0.500

High

226514

PSA4
Proteasome subunit alpha type-4

1

1

High-throughput

0.500

High

226515

PSA5
Proteasome subunit alpha type-5

1

1

High-throughput

0.500

High

226523

EMD
Emerin

1

2

High-throughput

0.500

High

226525

PSME3
Proteasome activator complex subunit 3

1

2

High-throughput

0.500

High

226540

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.500

High

226545

ILF2
Interleukin enhancer-binding factor 2

1

2

High-throughput

0.500

High

226546

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.500

High

226556

DREB
Drebrin

1

5

High-throughput

0.500

High

226566

PABP2
Polyadenylate-binding protein 2

1

2

High-throughput

0.500

High

226571

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

High-throughput

0.500

High

226573

LS14A
Protein LSM14 homolog A

1

9

High-throughput

0.500

High

226594

PDIP3
Polymerase delta-interacting protein 3

1

2

High-throughput

0.500

High

226611

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

3

High-throughput

0.500

High

226627

STRAP
Serine-threonine kinase receptor-associated protein

1

7

High-throughput

0.500

High

226524

RT29
Small ribosomal subunit protein mS29

1

1

High-throughput

0.489

High

226532

RT05
Small ribosomal subunit protein uS5m

1

1

High-throughput

0.489

High

226626

RT23
Small ribosomal subunit protein mS23

1

2

High-throughput

0.489

High

226552

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.479

High

226593

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.479

High

226597

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.479

High

226622

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.479

High

134978

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

3

High-throughput

0.479

High

138954

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

154588

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

161379

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

174288

ZN609
Zinc finger protein 609

1

16

High-throughput

0.479

High

226500

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

7

High-throughput

0.479

High

226501

NCOR1
Nuclear receptor corepressor 1

1

20

High-throughput

0.479

High

226503

PIAS1
E3 SUMO-protein ligase PIAS1

1

4

High-throughput

0.479

High

226505

WIZ
Protein Wiz

1

9

High-throughput

0.479

High

226508

ATX1L
Ataxin-1-like

1

5

High-throughput

0.479

High

226509

SKI
Ski oncogene

1

2

High-throughput

0.479

High

226510

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

20

High-throughput

0.479

High

226512

CSK22
Casein kinase II subunit alpha'

1

13

High-throughput

0.479

High

226526

DCAF7
DDB1- and CUL4-associated factor 7

1

5

High-throughput

0.479

High

226538

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

226539

TLE4
Transducin-like enhancer protein 4

1

20

High-throughput

0.479

High

226542

TLE5
TLE family member 5

1

20

High-throughput

0.479

High

226548

PWP1
Periodic tryptophan protein 1 homolog

1

7

High-throughput

0.479

High

226549

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

15

High-throughput

0.479

High

226558

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

High-throughput

0.479

High

226560

NIPBL
Nipped-B-like protein

1

6

High-throughput

0.479

High

226561

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

10

High-throughput

0.479

High

226562

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

226563

PAXI1
PAX-interacting protein 1

1

12

High-throughput

0.479

High

226565

PCGF5
Polycomb group RING finger protein 5

1

10

High-throughput

0.479

High

226567

LDB1
LIM domain-binding protein 1

1

4

High-throughput

0.479

High

226568

PB1
Protein polybromo-1

1

6

High-throughput

0.479

High

226569

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

226570

DHX37
Probable ATP-dependent RNA helicase DHX37

1

3

High-throughput

0.479

High

226574

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

226575

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

226576

KDM2B
Lysine-specific demethylase 2B

1

4

High-throughput

0.479

High

226578

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

9

High-throughput

0.479

High

226579

DDX54
ATP-dependent RNA helicase DDX54

1

1

High-throughput

0.479

High

226580

RT27
Small ribosomal subunit protein mS27

1

2

High-throughput

0.479

High

226582

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

226583

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

226586

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

20

High-throughput

0.479

High

226587

ZN512
Zinc finger protein 512

1

5

High-throughput

0.479

High

226588

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

226589

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

226590

DDX50
ATP-dependent RNA helicase DDX50

1

2

High-throughput

0.479

High

226596

DDX24
ATP-dependent RNA helicase DDX24

1

3

High-throughput

0.479

High

226598

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

3

High-throughput

0.479

High

226599

ZN644
Zinc finger protein 644

1

12

High-throughput

0.479

High

226601

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

15

High-throughput

0.479

High

226605

HM20A
High mobility group protein 20A

1

20

High-throughput

0.479

High

226606

SSF1
Suppressor of SWI4 1 homolog

1

1

High-throughput

0.479

High

226610

DDX56
Probable ATP-dependent RNA helicase DDX56

1

6

High-throughput

0.479

High

226613

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

20

High-throughput

0.479

High

226614

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

8

High-throughput

0.479

High

226615

TCF20
Transcription factor 20

1

19

High-throughput

0.479

High

226617

PRR12
Proline-rich protein 12

1

20

High-throughput

0.479

High

226623

ZN281
Zinc finger protein 281

1

8

High-throughput

0.479

High

226628

NCOR2
Nuclear receptor corepressor 2

1

16

High-throughput

0.479

High

226521

NOP2
28S rRNA

1

0

High-throughput

0.458

High

226547

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.458

High

226551

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.458

High

226600

CCD86
Coiled-coil domain-containing protein 86

1

0

High-throughput

0.458

High

226603

MOV10
Helicase MOV-10

1

0

High-throughput

0.458

High

226616

MRT4
mRNA turnover protein 4 homolog

1

0

High-throughput

0.458

High

183547

RT12
Small ribosomal subunit protein uS12m

1

3

High-throughput

0.457

High

226519

HUTH
Histidine ammonia-lyase

1

1

High-throughput

0.457

High

226607

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.457

High

226504

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.437

High

226520

RBM34
RNA-binding protein 34

1

2

High-throughput

0.437

High

226529

RT22
Small ribosomal subunit protein mS22

1

2

High-throughput

0.437

High

226531

RT35
Small ribosomal subunit protein mS35

1

1

High-throughput

0.437

High

226534

RT09
Small ribosomal subunit protein uS9m

1

2

High-throughput

0.437

High

226543

TF3C1
General transcription factor 3C polypeptide 1

1

1

High-throughput

0.437

High

226550

GSE1
Genetic suppressor element 1

1

2

High-throughput

0.437

High

226559

RRP12
RRP12-like protein

1

1

High-throughput

0.437

High

226585

DDX27
Probable ATP-dependent RNA helicase DDX27

1

2

High-throughput

0.437

High

226592

PYGO2
Pygopus homolog 2

1

3

High-throughput

0.437

High

226595

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.437

High

226602

FBRS
Probable fibrosin-1

1

9

High-throughput

0.437

High

226604

FBSL
Fibrosin-1-like protein

1

9

High-throughput

0.437

High

226608

DDX18
ATP-dependent RNA helicase DDX18

1

1

High-throughput

0.437

High

226609

RBM28
RNA-binding protein 28

1

1

High-throughput

0.437

High

226612

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.437

High

226620

RT28
Small ribosomal subunit protein bS1m

1

1

High-throughput

0.437

High

226621

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.437

High

226624

RRP15
RRP15-like protein

1

1

High-throughput

0.437

High

226629

RT18B
Small ribosomal subunit protein mS40

1

2

High-throughput

0.437

High

226533

RT34
Small ribosomal subunit protein mS34

1

0

High-throughput

0.279

Low

226502

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.249

Low

226527

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.249

Low

226530

RT10
Small ribosomal subunit protein uS10m

1

0

High-throughput

0.249

Low

226554

PUM3
Pumilio homolog 3

1

0

High-throughput

0.249

Low

226572

KRI1
Protein KRI1 homolog

1

0

High-throughput

0.249

Low

226581

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.249

Low

226584

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.249

Low

226591

CHOLN
Protein cholesin

1

0

High-throughput

0.249

Low

226625

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025