HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: QCR1 (P31930)
Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)
Gene: UQCRC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35373701, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0031625 - ubiquitin protein ligase binding GO:0044877 - protein-containing complex binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 480
+	Hs
		226056 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MPPB_HUMAN (4-479): 1.74e-174: 500: 54.91
+	Hs
		227289 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MPPA_HUMAN (1-476): 1.77e-142: 420: 25.88
+	Hs
		226535 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		QCR2_HUMAN (14-471): 4.75e-117: 353: 21.43
+	Hs
		226421 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IDE_HUMAN (21-461): 1.05e-104: 336: 15.28
+	Hs
		475391 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		QCR1_HUMAN (1-480): 0: 537: 100.00
+	Zm
		10816 A0A1D6F853_MAIZE (204-462): 3.07e-69: 239: 19.70		B4FSZ7_MAIZE (2-474): 5.2e-130: 387: 25.52
+	At
		1091669 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		MPPB_ARATH (25-480): 7.63e-169: 488: 43.89
+	Sc
		477090 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		MPPA_YEAST (26-461): 2.63e-119: 359: 25.45
+	At
		1092462 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		MPPA1_ARATH (2-474): 1.06e-132: 394: 25.47
+	Hs
		475299 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		IDE_HUMAN (21-461): 1.05e-104: 336: 15.28