HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH3_1~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 450
+	Hs
		226199 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Hs
		226294 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		YES_HUMAN (12-442): 5.99e-170: 490: 37.30
+	Mm
		337640 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		ABL1_MOUSE (5-447): 5.69e-165: 495: 37.83
+	Hs
		226295 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Hs
		523051 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SRC_HUMAN (12-442): 8.48e-171: 491: 39.33
+	Hs
		337319 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Hs
		475292 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SRC_HUMAN (12-442): 8.48e-171: 491: 39.33
+	Hs
		411563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		LCK_HUMAN (5-443): 1.95e-168: 485: 38.55