HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043524 - negative regulation of neuron apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 596
+	Hs
		227239 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPCZ_HUMAN (15-596): 0: 631: 70.34
+	Hs
		227208 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPCE_HUMAN (43-590): 1.72e-177: 521: 36.23
+	Hs
		227243 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPCD_HUMAN (93-591): 2.71e-176: 516: 34.52
+	Rn
		448427 HOIL1_RAT (12-448): 8.73e-66: 221: 17.05		KPCZ_RAT (1-596): 0: 630: 69.37
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (187-586): 9.51e-152: 447: 39.36
+	Hs
		226637 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86
+	Hs
		228960 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KS6B2_HUMAN (245-592): 8.21e-147: 434: 38.64
+	Hs
		226918 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KS6A3_HUMAN (122-543): 1.57e-104: 333: 20.47
+	Hs
		682055 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (187-586): 9.51e-152: 447: 39.36
+	Hs
		474935 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86
+	Hs
		270450 RN19A_HUMAN (236-452): 6.6e-31: 128: 21.62		KS6A5_HUMAN (62-540): 2.04e-118: 371: 17.96
+	Hs
		226260 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPCB_HUMAN (111-229): 6.31e-18: 89.6: 21.28
+	Hs
		226455 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37
+	Hs
		408678 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		KPCB_HUMAN (111-229): 6.31e-18: 89.6: 21.28
+	Hs
		566475 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37
+	Rn
		934618 HOIL1_RAT (12-448): 8.73e-66: 221: 17.05		KPCB_RAT (111-229): 6.26e-18: 89.6: 21.28
+	Hs
		408534 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		KPCB_HUMAN (111-229): 6.31e-18: 89.6: 21.28
+	Hs
		408535 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KPCB_HUMAN (111-229): 6.31e-18: 89.6: 21.28
+	Hs
		475314 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37