HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: MAP1B (P46821)
Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]
Gene: MAP1B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35987950
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0014069 - postsynaptic density GO:0044877 - protein-containing complex binding GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 2468
+	Hs
		228019 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AGRG4_HUMAN (433-2391): 8.42e-51: 202: 9.33
+	Hs
		227747 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MAP1S_HUMAN (1859-2468): 1.33e-37: 157: 16.39
+	Hs
		227149 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MAP1A_HUMAN (435-2356): 1.52e-28: 128: 8.19
+	Hs
		228210 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TITIN_HUMAN (362-1320): 1.1e-10: 69.8: 8.51
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (366-2031): 6.1e-10: 67.5: 7.40
+	Hs
		475350 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		APC_HUMAN (603-2214): 4.09e-44: 180: 9.80
+	Hs
		475943 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OTOG_HUMAN (1784-2375): 6.04e-36: 153: 13.92
+	At
		1092118 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9LIE8_ARATH (355-1217): 3.68e-30: 133: 8.45
+	Hs
		476121 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MUC16_HUMAN (331-2361): 1.92e-26: 122: 9.33
+	Hs
		476650 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NCOR2_HUMAN (334-2072): 6.72e-15: 83.7: 6.77