HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSMD7 (P51665)
26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Mov34 protein homolog) (Proteasome subunit p40)
Gene: PSMD7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35256949, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	JAB~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 324
+	Hs
		227878 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CSN6_HUMAN (8-286): 1.73e-102: 305: 24.47
+	Hs
		124687 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EIF3F_HUMAN (2-279): 1.1e-98: 297: 26.88
+	Hs
		176889 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EIF3H_HUMAN (3-275): 1.64e-66: 214: 17.65
+	Hs
		228258 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CSN5_HUMAN (7-160): 1.07e-41: 149: 19.38
+	Sc
		477476 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RPN8_YEAST (7-322): 1.4e-99: 298: 47.01
+	Hs
		475500 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSMD7_HUMAN (1-285): 5.24e-110: 324: 100.00
+	At
		188941 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD7A_ARATH (1-289): 1.39e-106: 315: 61.03
+	At
		1091969 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD7B_ARATH (1-289): 1.06e-105: 313: 59.66
+	Hs
		475966 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CSN6_HUMAN (8-286): 1.73e-102: 305: 24.47
+	Hs
		124740 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		EIF3F_HUMAN (2-279): 1.1e-98: 297: 26.88
+	At
		1091853 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CSN6A_ARATH (2-290): 9e-90: 272: 22.22
+	At
		137953 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		EIF3F_ARATH (2-281): 4.43e-81: 249: 27.40
+	Hs
		176926 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		EIF3H_HUMAN (3-275): 1.64e-66: 214: 17.65
+	At
		1091793 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CSN5A_ARATH (7-161): 1.07e-49: 171: 19.88
+	Hs
		476142 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CSN5_HUMAN (7-160): 1.07e-41: 149: 19.38
+	At
		1092172 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSDE_ARATH (7-142): 6.48e-31: 120: 26.76