Protein: UBP18
Ubl carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (43 kDa ISG15-specific protease) (hUBP43) (ISG15-specific-processing protease) (Ubl thioesterase 18)

Gene: UBP18, USP18
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q9UMW8

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

425676

ISG15
Ubiquitin-like protein ISG15

11

20

Small-scale

0.978

High

913171

STAT2
Signal transducer and activator of transcription 2

6

7

Small-scale

0.733

High

1101930

SKP2
S-phase kinase-associated protein 2

4

6

Small-scale

0.698

High

214065

M3K7
Mitogen-activated protein kinase kinase kinase 7

4

5

Small-scale

0.676

High

566075

EF2
Elongation factor 2

1

5

Small-scale

0.618

High

987267

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

Small-scale

0.618

High

996388

EF1A1
Elongation factor 1-alpha 1

1

8

Small-scale

0.618

High

1051889

EF1A2
Elongation factor 1-alpha 2

1

8

Small-scale

0.618

High

1153232

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

16

High-throughput

0.618

High

731699

STIP1
Stress-induced-phosphoprotein 1

2

6

Small-scale

0.584

High

857593

NOTC1
Neurogenic locus notch homolog protein 1

2

13

Small-scale

0.584

High

1060247

B2CL1
Bcl-2-like protein 1

2

2

Small-scale

0.584

High

1153139

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

2

1

Small-scale

0.584

High

1462095

NEMO
NF-kappa-B essential modulator

2

20

Small-scale

0.584

High

1151980

TWST1
Twist-related protein 1

1

8

Small-scale

0.561

High

1454903

UVRAG
UV radiation resistance-associated gene protein

2

0

Small-scale

0.559

High

1307677

ZDH17
Palmitoyltransferase ZDHHC17

1

6

High-throughput

0.541

High

584819

NDKA
Nucleoside diphosphate kinase A

1

1

High-throughput

0.536

High

952669

MYL6
Myosin light polypeptide 6

1

4

High-throughput

0.536

High

844091

HD
Huntingtin

1

2

High-throughput

0.515

High

1419266

TRI54
Tripartite motif-containing protein 54

1

20

High-throughput

0.501

High

1273171

KDM3B
Lysine-specific demethylase 3B

1

6

High-throughput

0.489

High

160644

IRS4
Insulin receptor substrate 4

1

3

Small-scale

0.479

High

167997

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

10

Small-scale

0.479

High

177961

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

16

Small-scale

0.479

High

188390

HDAC3
Histone deacetylase 3

1

9

Small-scale

0.479

High

226913

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

9

High-throughput

0.479

High

350179

SNAI1
Zinc finger protein SNAI1

1

11

Small-scale

0.479

High

551333

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.479

High

755028

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.479

High

765117

CTNB1
Catenin beta-1

1

16

Small-scale

0.479

High

790108

ZEB1
Zinc finger E-box-binding homeobox 1

1

11

Small-scale

0.479

High

838258

STAT6
Signal transducer and activator of transcription 6

1

7

Small-scale

0.479

High

873131

SOX9
Transcription factor SOX-9

1

17

Small-scale

0.479

High

881338

FAS
Fatty acid synthase

1

4

Small-scale

0.479

High

946220

MLF1
Myeloid leukemia factor 1

1

1

High-throughput

0.479

High

980539

H4
Histone H4

1

7

Small-scale

0.479

High

1008401

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

Small-scale

0.479

High

1062715

DHX9
ATP-dependent RNA helicase A

1

14

Small-scale

0.479

High

1106123

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

High-throughput

0.479

High

1108752

TBB3
Tubulin beta-3 chain

1

14

Small-scale

0.479

High

1126786

BECN1
Beclin-1

1

2

Small-scale

0.479

High

1253015

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

Small-scale

0.479

High

1278147

MAVS
Mitochondrial antiviral-signaling protein

1

16

Small-scale

0.479

High

1280598

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

12

Small-scale

0.479

High

1292890

STING
Stimulator of interferon genes protein

1

8

Small-scale

0.479

High

1308611

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.479

High

1323186

CCAR2
Cell cycle and apoptosis regulator protein 2

1

3

Small-scale

0.479

High

1337326

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

1

Small-scale

0.479

High

1403265

RSF1
Remodeling and spacing factor 1

1

20

Small-scale

0.479

High

1405819

TTC1
Tetratricopeptide repeat protein 1

1

7

High-throughput

0.479

High

1413506

AASD1
Alanyl-tRNA editing protein Aarsd1

1

2

High-throughput

0.479

High

1417020

CAR11
Caspase recruitment domain-containing protein 11

1

4

Small-scale

0.479

High

1417792

KDM5D
Lysine-specific demethylase 5D

1

7

Small-scale

0.479

High

1420381

TRI31
E3 ubiquitin-protein ligase TRIM31

1

20

Small-scale

0.479

High

1452634

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

6

Small-scale

0.479

High

1460459

FKBPL
FK506-binding protein-like

1

9

High-throughput

0.479

High

1462092

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

Small-scale

0.479

High

1462094

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

3

Small-scale

0.479

High

959092

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

1437977

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

76588

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

4

High-throughput

0.437

High

326798

DUS14
Dual specificity protein phosphatase 14

1

10

Small-scale

0.437

High

1245585

Q6PK50
HSP90AB1 protein

1

7

High-throughput

0.437

High

1384548

Q96BE0
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.437

High

1409576

Q9BPW0
Serine/threonine-protein phosphatase

1

5

High-throughput

0.437

High

873923

INAR2
Interferon alpha/beta receptor 2

5

0

Small-scale

0.368

High

1462093

TM14A
Transmembrane protein 14A

1

0

High-throughput

0.265

Low

1119540

PEBB
Core-binding factor subunit beta

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025