HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.960

The method score is based on:

Property Details
Experiments 29643511, 25375667, 24647965, 17553932, 12150907, 21694720, 20940148
Identification Methods pull down
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains UQ_con~ubiquitin, UQ_con~zf-RING_14
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005829 - cytosol
and 6 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 465
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024