Protein: SYK
Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)

Gene: SYK, KARS1
Organism: Homo sapiens
Interactions: 234
UniProt ID: Q15046

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002276 - basophil activation involved in immune response
GO:0002863 - positive regulation of inflammatory response to antigenic stimulus
GO:0003877 - ATP:ADP adenylyltransferase activity
GO:0004824 - lysine-tRNA ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1096544

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

20

6

Small-scale

0.990

High

1139615

SYK
Lysine--tRNA ligase

3

14

Small-scale

0.872

High

576771

SYDC
Aspartate--tRNA ligase, cytoplasmic

2

13

High-throughput

0.811

High

460537

SYEP
Bifunctional glutamate/proline--tRNA ligase

5

20

Small-scale

0.716

High

476692

RSSA
Small ribosomal subunit protein uS2

3

7

Small-scale

0.691

High

372071

MYC
Myc proto-oncogene protein

4

4

High-throughput

0.672

High

1089302

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

3

9

Small-scale

0.662

High

1139636

SDCG8
Serologically defined colon cancer antigen 8

3

4

Small-scale

0.662

High

60504

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

10

High-throughput

0.628

High

214207

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

2

12

High-throughput

0.628

High

834453

SYIC
Isoleucine--tRNA ligase, cytoplasmic

2

11

High-throughput

0.628

High

868169

SYQ
Glutamine--tRNA ligase

2

14

High-throughput

0.628

High

926475

SYRC
Arginine--tRNA ligase, cytoplasmic

2

4

High-throughput

0.628

High

940249

SYMC
Methionine--tRNA ligase, cytoplasmic

2

11

High-throughput

0.628

High

1139692

SYLC
Leucine--tRNA ligase, cytoplasmic

2

14

High-throughput

0.628

High

1139629

SYDM
Aspartate--tRNA ligase, mitochondrial

1

13

Small-scale

0.621

High

695502

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.618

High

768235

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.618

High

241721

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

631229

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

934632

TERA
Transitional endoplasmic reticulum ATPase

2

5

High-throughput

0.571

High

218200

TGON2
Trans-Golgi network integral membrane protein 2

2

0

High-throughput

0.563

High

703596

MK01
Mitogen-activated protein kinase 1

1

2

Small-scale

0.561

High

1139674

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

557314

SRC
Proto-oncogene tyrosine-protein kinase Src

2

0

High-throughput

0.547

High

1139664

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

688007

EF1G
Elongation factor 1-gamma

1

7

High-throughput

0.541

High

845303

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

7

High-throughput

0.541

High

140275

SDCB1
Syntenin-1

1

1

High-throughput

0.536

High

215566

EMC8
ER membrane protein complex subunit 8

1

3

High-throughput

0.536

High

389371

FINC
Fibronectin

1

2

High-throughput

0.536

High

902267

RB27A
Ras-related protein Rab-27A

1

2

High-throughput

0.536

High

944384

SYJ2B
Synaptojanin-2-binding protein

1

1

High-throughput

0.536

High

969872

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

1112492

CUL1
Cullin-1

1

7

High-throughput

0.536

High

1136014

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

1139620

PKN2
Serine/threonine-protein kinase N2

1

2

High-throughput

0.536

High

1139641

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.536

High

1139658

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.536

High

1139670

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

5

High-throughput

0.536

High

1139702

EMC9
ER membrane protein complex subunit 9

1

3

High-throughput

0.536

High

297351

DYSF
Dysferlin

1

0

High-throughput

0.518

High

552245

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.518

High

188889

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.515

High

352444

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.515

High

459291

CATL1
Procathepsin L

1

2

High-throughput

0.515

High

560397

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.515

High

692970

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

830765

CCNF
Cyclin-F

1

3

High-throughput

0.515

High

1031376

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.515

High

1139652

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.515

High

1139699

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.515

High

361251

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.515

High

271528

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

1123291

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

1139645

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.513

High

1139651

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

1139669

SCN2A
Sodium channel protein type 2 subunit alpha

1

0

High-throughput

0.513

High

1139680

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

1139697

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

1139705

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

408885

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.508

High

474689

VIME
Vimentin

1

1

High-throughput

0.508

High

1139654

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

4

High-throughput

0.508

High

185712

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

396140

ESR1
Estrogen receptor

1

5

Small-scale

0.501

High

462877

LAMB1
Laminin subunit beta-1

1

1

Small-scale

0.501

High

955185

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.501

High

964292

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.501

High

124920

GTPB1
GTP-binding protein 1

1

14

High-throughput

0.479

High

129098

MEN1
Menin

1

2

High-throughput

0.479

High

132049

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.479

High

176064

KDM6B
Lysine-specific demethylase 6B

1

3

Small-scale

0.479

High

194198

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

259972

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

293707

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

315600

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

319775

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

324877

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

345843

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

400854

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

404062

GCR
Glucocorticoid receptor

1

5

Small-scale

0.479

High

411960

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

445890

ENOA
Alpha-enolase

1

4

High-throughput

0.479

High

460822

CATB
Cathepsin B

1

3

High-throughput

0.479

High

468385

HS90B
Heat shock protein HSP 90-beta

1

8

High-throughput

0.479

High

471031

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.479

High

482482

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.479

High

520059

ANDR
Androgen receptor

1

5

Small-scale

0.479

High

537192

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

541494

FGFR1
Fibroblast growth factor receptor 1

1

10

High-throughput

0.479

High

582804

EZRI
Ezrin

1

2

High-throughput

0.479

High

588738

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

606786

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

610002

VGFR1
Vascular endothelial growth factor receptor 1

1

5

High-throughput

0.479

High

640170

EPHA1
Ephrin type-A receptor 1

1

5

High-throughput

0.479

High

650168

FGFR3
Fibroblast growth factor receptor 3

1

10

High-throughput

0.479

High

680705

CATS
Cathepsin S

1

2

High-throughput

0.479

High

681376

PSA3
Proteasome subunit alpha type-3

1

1

Small-scale

0.479

High

711892

LTK
Leukocyte tyrosine kinase receptor

1

7

High-throughput

0.479

High

720230

UFO
Tyrosine-protein kinase receptor UFO

1

7

High-throughput

0.479

High

731312

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

766568

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

777690

VGFR3
Vascular endothelial growth factor receptor 3

1

5

High-throughput

0.479

High

787022

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.479

High

799133

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.479

High

824155

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.479

High

861168

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

867144

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.479

High

872347

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

879105

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

888078

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

901823

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

903918

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

926995

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

959162

ABCE1
ATP-binding cassette sub-family E member 1

1

9

High-throughput

0.479

High

964959

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.479

High

970527

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

979684

H4
Histone H4

1

3

High-throughput

0.479

High

992483

RS21
Small ribosomal subunit protein eS21

1

1

High-throughput

0.479

High

1024584

VIGLN
Vigilin

1

3

High-throughput

0.479

High

1049155

RON
Macrophage-stimulating protein receptor

1

8

High-throughput

0.479

High

1088182

MERTK
Tyrosine-protein kinase Mer

1

7

High-throughput

0.479

High

1092132

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

1099914

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

1106888

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1113140

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1114830

CUL4A
Cullin-4A

1

7

High-throughput

0.479

High

1122486

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.479

High

1131033

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

7

Small-scale

0.479

High

1136204

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.479

High

1137696

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1138220

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1139616

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1139617

PDK1
[Pyruvate dehydrogenase

1

4

High-throughput

0.479

High

1139621

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1139622

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1139625

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.479

High

1139626

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1139628

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.479

High

1139630

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1139631

LMTK1
Serine/threonine-protein kinase LMTK1

1

7

High-throughput

0.479

High

1139632

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1139633

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

1139635

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

1139637

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.479

High

1139638

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

1139639

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1139642

LMTK2
Serine/threonine-protein kinase LMTK2

1

8

High-throughput

0.479

High

1139648

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.479

High

1139653

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1139655

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

1139660

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

1139662

ARMC5
Armadillo repeat-containing protein 5

1

4

High-throughput

0.479

High

1139663

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

1139665

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1139667

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1139668

LMTK3
Serine/threonine-protein kinase LMTK3

1

12

High-throughput

0.479

High

1139671

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

1139676

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

1139681

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

1139682

ANLN
Anillin

1

2

High-throughput

0.479

High

1139683

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1139684

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

1139686

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1139687

MDN1
Midasin

1

1

High-throughput

0.479

High

1139691

RN181
E3 ubiquitin-protein ligase RNF181

1

1

High-throughput

0.479

High

1139693

HDAC6
Protein deacetylase HDAC6

1

4

High-throughput

0.479

High

1139694

DUX4
Double homeobox protein 4

1

1

High-throughput

0.479

High

1139695

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1139696

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

1

High-throughput

0.479

High

1139700

FAF1
FAS-associated factor 1

1

1

High-throughput

0.479

High

1139703

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

1117365

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

0

Small-scale

0.460

High

123391

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

164341

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

290002

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

290931

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.458

High

390581

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

488792

FURIN
Furin

1

0

High-throughput

0.458

High

559961

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

774363

BASI
Basigin

1

0

High-throughput

0.458

High

810111

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

832720

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.458

High

904730

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

976278

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

1026391

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1028204

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1047419

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.458

High

1139619

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1139624

SPOUT
28S rRNA

1

0

High-throughput

0.458

High

1139627

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1139634

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1139646

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1139649

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

0

High-throughput

0.458

High

1139650

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

0

Small-scale

0.458

High

1139656

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.458

High

1139659

H2B1H
Histone H2B type 1-H

1

0

High-throughput

0.458

High

1139666

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

1139672

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.458

High

1139673

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1139678

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

1139679

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

1139685

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

1139688

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1139689

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1139690

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

1139704

PPME1
Protein phosphatase methylesterase 1

1

0

Small-scale

0.458

High

255028

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.445

High

429917

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

535915

CD37
Leukocyte antigen CD37

1

2

Small-scale

0.445

High

563786

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.445

High

952175

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.445

High

1139623

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

1139647

MSPD2
Motile sperm domain-containing protein 2

1

3

High-throughput

0.445

High

1139675

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.445

High

1139677

VIAAT
Vesicular inhibitory amino acid transporter

1

2

High-throughput

0.445

High

1139701

ST38L
Serine/threonine-protein kinase 38-like

1

2

High-throughput

0.445

High

220244

FRS3
Fibroblast growth factor receptor substrate 3

1

0

High-throughput

0.438

High

1139657

CELF1
CUGBP Elav-like family member 1

1

0

High-throughput

0.438

High

105960

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

179902

BET1
BET1 homolog

1

2

High-throughput

0.437

High

1139640

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.437

High

1139661

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.437

High

1139698

HECD1
E3 ubiquitin-protein ligase HECTD1

1

4

High-throughput

0.437

High

1034445

TAGL
Transgelin

1

0

High-throughput

0.426

High

1086594

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.426

High

1139618

NEDD8
Ubiquitin-like protein NEDD8

1

0

Small-scale

0.426

High

886873

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

1139706

LRRF2
Leucine-rich repeat flightless-interacting protein 2

2

0

High-throughput

0.328

High

1139643

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1139644

FSAF1
40S small subunit processome assembly factor 1

1

0

High-throughput

0.249

Low

516840

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025