HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35987950, 35256949
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH3_1~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0017124 - SH3 domain binding and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 217
+	Hs
		226747 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		226199 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Mm
		337640 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46
+	Hs
		226294 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		226295 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		474986 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		475592 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		523051 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		855831 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18
+	Hs
		411563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		337319 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		476483 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		475816 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		475292 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58