Protein: SYDM
Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)

Gene: SYDM, DARS2
Organism: Homo sapiens
Interactions: 142
UniProt ID: Q6PI48

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0004815 - aspartate-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

532687

CH60
60 kDa heat shock protein, mitochondrial

4

1

High-throughput

0.697

High

348571

AIFM1
Apoptosis-inducing factor 1, mitochondrial

4

2

High-throughput

0.683

High

1244587

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.656

High

914640

RM12
Large ribosomal subunit protein bL12m

3

0

High-throughput

0.634

High

1139629

SYK
Lysine--tRNA ligase

1

13

Small-scale

0.621

High

695743

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.618

High

768464

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.618

High

1244589

MTG2
Mitochondrial ribosome-associated GTPase 2

2

3

High-throughput

0.611

High

946500

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.602

High

242034

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

932890

P5CS
Delta-1-pyrroline-5-carboxylate synthase

2

0

High-throughput

0.580

High

1244596

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.576

High

293874

CD123
Translation initiation factor eIF2 assembly protein

2

2

High-throughput

0.571

High

156297

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

2

2

High-throughput

0.567

High

1107840

SQSTM
Sequestosome-1

2

0

High-throughput

0.559

High

1096570

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

6

Small-scale

0.555

High

1244551

TSN33
Tetraspanin-33

2

2

High-throughput

0.553

High

1244583

TR61B
tRNA

2

0

High-throughput

0.547

High

563933

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.541

High

710718

EPHA8
Ephrin type-A receptor 8

1

5

High-throughput

0.541

High

288238

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

1

High-throughput

0.536

High

349683

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

1

High-throughput

0.536

High

842219

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

1

High-throughput

0.536

High

945708

FOXL2
Forkhead box protein L2

1

5

High-throughput

0.536

High

1244559

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

4

High-throughput

0.536

High

1244582

MYL10
Myosin regulatory light chain 10

1

1

High-throughput

0.536

High

1244585

LDH6B
L-lactate dehydrogenase A-like 6B

1

2

High-throughput

0.536

High

1244597

DIC
Mitochondrial dicarboxylate carrier

1

1

High-throughput

0.536

High

1244598

NPS3A
Protein NipSnap homolog 3A

1

1

High-throughput

0.536

High

1244602

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

1244606

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

1244607

RT02
Small ribosomal subunit protein uS2m

1

4

High-throughput

0.536

High

830939

CCNF
Cyclin-F

1

3

High-throughput

0.515

High

275315

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

289785

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

690512

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

869181

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

1238398

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

1242584

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1244549

RM21
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.513

High

1244554

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1244556

ETKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

1

0

High-throughput

0.513

High

1244566

GLYL1
Glycine N-acyltransferase-like protein 1

1

0

High-throughput

0.513

High

1244572

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1244573

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

1244581

FEM1A
Protein fem-1 homolog A

1

0

High-throughput

0.513

High

1244584

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

1

0

High-throughput

0.513

High

1244592

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.513

High

1244594

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.513

High

1244601

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

1244579

DPYL5
Dihydropyrimidinase-related protein 5

1

3

High-throughput

0.494

High

1244574

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.493

High

288105

FOXH1
Forkhead box protein H1

1

5

High-throughput

0.489

High

867217

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.489

High

1022109

SHC2
SHC-transforming protein 2

1

5

High-throughput

0.489

High

1091301

FOXL1
Forkhead box protein L1

1

5

High-throughput

0.489

High

1244547

FOXI2
Forkhead box protein I2

1

5

High-throughput

0.489

High

1244569

TRI43
Tripartite motif-containing protein 43

1

1

High-throughput

0.489

High

1244576

RSLAB
Ras-like protein family member 10B

1

2

High-throughput

0.489

High

1244578

FOXB1
Forkhead box protein B1

1

6

High-throughput

0.489

High

1244605

KLH20
Kelch-like protein 20

1

1

High-throughput

0.489

High

129191

MEN1
Menin

1

2

High-throughput

0.479

High

279800

CISY
Citrate synthase, mitochondrial

1

2

High-throughput

0.479

High

315699

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

372336

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

406294

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.479

High

412114

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

471090

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.479

High

529974

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.479

High

588957

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

720260

UFO
Tyrosine-protein kinase receptor UFO

1

7

High-throughput

0.479

High

766641

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

856292

IF2M
Translation initiation factor IF-2, mitochondrial

1

9

High-throughput

0.479

High

879201

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

1090439

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

7

High-throughput

0.479

High

1100024

TIF1B
Transcription intermediary factor 1-beta

1

4

High-throughput

0.479

High

1106964

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1113437

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1117761

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

3

High-throughput

0.479

High

1138326

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1140437

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1142575

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

1149094

SF3A1
Splicing factor 3A subunit 1

1

3

High-throughput

0.479

High

1207046

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1244550

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

High-throughput

0.479

High

1244570

OPTN
Optineurin

1

3

High-throughput

0.479

High

1244577

DNJC2
DnaJ homolog subfamily C member 2

1

4

High-throughput

0.479

High

1244595

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

1196844

Q4VAQ0
COL8A2 protein

1

1

High-throughput

0.470

High

1244586

THS7B
Thrombospondin type-1 domain-containing protein 7B

1

1

High-throughput

0.470

High

143060

NFIB
Nuclear factor 1 B-type

1

0

High-throughput

0.458

High

519142

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

1048563

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1058090

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1149914

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.458

High

1162383

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1234419

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1244553

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

1244567

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

1244568

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

1244599

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

0

High-throughput

0.458

High

539350

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

2

High-throughput

0.445

High

1244558

PTGR3
Prostaglandin reductase 3

1

3

High-throughput

0.445

High

1244603

NFU1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

1

1

High-throughput

0.445

High

668786

CO8A2
Collagen alpha-2(VIII) chain

1

1

High-throughput

0.439

High

106124

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

319849

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.437

High

962176

RHOA
Transforming protein RhoA

1

1

High-throughput

0.437

High

1220573

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.437

High

1244546

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1244548

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1244557

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

1244571

ARHGQ
Rho guanine nucleotide exchange factor 26

1

1

High-throughput

0.437

High

1244590

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

653392

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1226138

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.426

High

1244564

SPT20
Spermatogenesis-associated protein 20

1

0

High-throughput

0.426

High

1244580

MGME1
Mitochondrial genome maintenance exonuclease 1

1

0

High-throughput

0.426

High

1244588

GCP60
Golgi resident protein GCP60

1

0

Small-scale

0.426

High

1244591

NT5D2
5'-nucleotidase domain-containing protein 2

1

0

High-throughput

0.426

High

1226899

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.407

High

1244560

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

1244604

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

162213

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

2

0

High-throughput

0.316

High

883421

CY561
Transmembrane ascorbate-dependent reductase CYB561

2

0

High-throughput

0.316

High

1050031

PLP2
Proteolipid protein 2

2

0

High-throughput

0.316

High

1164216

AOC3
Amine oxidase [copper-containing] 3

2

0

High-throughput

0.316

High

1200094

UNC50
Protein unc-50 homolog

2

0

High-throughput

0.316

High

1244565

TM239
Transmembrane protein 239

2

0

High-throughput

0.316

High

1244600

FETUB
Fetuin-B

2

0

High-throughput

0.316

High

723933

LCN1
Lipocalin-1

1

0

High-throughput

0.279

Low

1244562

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.279

Low

1244563

CC4L
C-C motif chemokine 4-like

1

0

High-throughput

0.279

Low

1244593

CT096
Uncharacterized protein C20orf96

1

0

High-throughput

0.279

Low

1244561

FBX15
F-box only protein 15

1

0

High-throughput

0.269

Low

1042635

UPAR
Urokinase plasminogen activator surface receptor

1

0

High-throughput

0.249

Low

1161014

FSCN1
Fascin

1

0

High-throughput

0.249

Low

1178209

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1244552

Q86V94
LOC554223 protein

1

0

High-throughput

0.249

Low

844806

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.232

Low

1244555

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.232

Low

1244575

CC120
Coiled-coil domain-containing protein 120

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025