HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: EF1A1 (P68104)
Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7)
Gene: EEF1A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	25959826, 32929329, 35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019900 - kinase binding GO:0019901 - protein kinase binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 462
+	Hs
		227242 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EF1A2_HUMAN (1-461): 0: 567: 92.63
+	Hs
		226427 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ERF3A_HUMAN (2-443): 3.59e-162: 469: 37.47
+	Hs
		228009 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ERF3B_HUMAN (2-443): 1.29e-159: 467: 36.12
+	Hs
		229149 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HBS1L_HUMAN (5-443): 5.78e-158: 464: 38.95
+	Hs
		312566 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		EF1A1_HUMAN (1-462): 0: 578: 100.00
+	Sc
		367642 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		EF1A_YEAST (1-445): 0: 538: 80.90
+	Xl
		568008 Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33		EF1A2_XENLA (1-461): 0: 564: 91.11
+	Hs
		1377778 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		HBS1L_HUMAN (5-443): 5.78e-158: 464: 38.95
+	Hs
		475654 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		EF1A2_HUMAN (1-461): 0: 567: 92.63
+	At
		1012702 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		EF1A3_ARATH (1-461): 0: 527: 74.84
+	Zm
		24723 A0A1D6IJX7_MAIZE (233-459): 1.19e-26: 116: 21.70		B6UHJ4_MAIZE (1-448): 0: 518: 77.01
+	Zm
		24695 A0A1D6IJX7_MAIZE (233-459): 1.19e-26: 116: 21.70		A0A1D6M1G2_MAIZE (1-448): 0: 515: 76.33
+	Hs
		476620 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		HBS1L_HUMAN (5-443): 5.78e-158: 464: 38.95