HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TCPB (P78371)
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)
Gene: CCT2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	25959826, 32929329, 35509820, 35256949, 14532270
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0050821 - protein stabilization
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 535
+	Hs
		228487 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TCPH_HUMAN (4-532): 0: 591: 34.08
+	Hs
		226839 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TCPG_HUMAN (3-532): 0: 561: 28.33
+	Hs
		226467 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TCPA_HUMAN (5-533): 0: 541: 34.30
+	Hs
		226819 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Hs
		476269 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TCPH_HUMAN (4-532): 0: 591: 34.08
+	Hs
		475612 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TCPB_HUMAN (1-535): 0: 586: 100.00
+	Hs
		475479 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TCPG_HUMAN (3-532): 0: 561: 28.33
+	At
		1091899 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TCPB_ARATH (6-530): 0: 554: 67.43
+	Hs
		475319 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TCPA_HUMAN (5-533): 0: 541: 34.30
+	Hs
		475476 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TCPE_HUMAN (1-528): 0: 541: 32.29
+	At
		138353 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TCPE_ARATH (6-523): 0: 539: 30.87
+	At
		660202 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TCPA_ARATH (16-522): 2.27e-85: 276: 35.08