HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PRAME (P78395)
Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma)
Gene: PRAME

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26186194
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 509
+	Hs
		475613 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRAME_HUMAN (1-509): 0: 525: 100.00
+	Hs
		228404 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLRP3_HUMAN (209-459): 7.35e-50: 186: 15.83
+	Hs
		228349 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TONSL_HUMAN (195-487): 3.35e-30: 127: 20.18
+	Mm
		1246904 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		NLRP3_MOUSE (92-409): 1.14e-32: 134: 15.60
+	Hs
		226392 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RINI_HUMAN (324-458): 5.19e-18: 88.6: 20.00
+	Hs
		227942 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NAL13_HUMAN (227-452): 4.01e-12: 70.9: 15.87
+	Hs
		312647 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		NLRP3_HUMAN (209-459): 7.35e-50: 186: 15.83
+	Hs
		476115 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NALP7_HUMAN (214-490): 5.81e-28: 120: 15.57