HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: S25A3 (Q00325)
Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP)
Gene: SLC25A3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	32929329, 35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0044877 - protein-containing complex binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 362
+	Hs
		959252 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		S25A3_HUMAN (1-362): 2.64e-98: 297: 100.00
+	Hs
		227780 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SCMC1_HUMAN (150-361): 7.77e-42: 153: 17.20
+	Hs
		227774 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SCMC2_HUMAN (163-361): 1.53e-40: 150: 16.35
+	Hs
		226076 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		S2512_HUMAN (20-163): 4.6e-25: 108: 16.67
+	Hs
		229010 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		S2513_HUMAN (267-359): 4.19e-16: 81.5: 20.56
+	Hs
		226378 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ADT1_HUMAN (262-359): 1.01e-11: 66.8: 17.86
+	Hs
		226379 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ADT3_HUMAN (257-359): 9.71e-12: 66.8: 17.09
+	Hs
		226250 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ADT2_HUMAN (262-359): 1.56e-11: 66.4: 16.96
+	Hs
		1317097 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		S2513_HUMAN (267-359): 4.19e-16: 81.5: 20.56
+	Hs
		476538 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		S2513_HUMAN (267-359): 4.19e-16: 81.5: 20.56
+	Hs
		476087 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		S2540_HUMAN (97-341): 1.12e-13: 73.2: 22.99