Protein: CLK1
Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)

Gene: CLK1
Organism: Homo sapiens
Interactions: 214
UniProt ID: P49759

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

889406

SRSF1
Serine/arginine-rich splicing factor 1

7

20

Small-scale

0.965

High

889417

TRA2A
Transformer-2 protein homolog alpha

5

20

High-throughput

0.929

High

889375

CLK2
Dual specificity protein kinase CLK2

5

17

High-throughput

0.927

High

889428

SRSF7
Serine/arginine-rich splicing factor 7

4

20

High-throughput

0.897

High

284094

SRS10
Serine/arginine-rich splicing factor 10

3

20

Small-scale

0.874

High

889391

TRA2B
Transformer-2 protein homolog beta

3

20

High-throughput

0.849

High

889396

SRSF3
Serine/arginine-rich splicing factor 3

5

20

Small-scale

0.822

High

889394

SRPK2
SRSF protein kinase 2

2

18

High-throughput

0.800

High

889374

CLK1
Dual specificity protein kinase CLK1

2

17

Small-scale

0.755

High

889413

SRSF5
Serine/arginine-rich splicing factor 5

2

20

High-throughput

0.714

High

889414

SRSF6
Serine/arginine-rich splicing factor 6

2

20

High-throughput

0.714

High

889487

SRPK1
SRSF protein kinase 1

1

18

High-throughput

0.710

High

154423

SH2B2
SH2B adapter protein 2

2

14

High-throughput

0.700

High

889403

SRS11
Serine/arginine-rich splicing factor 11

1

9

High-throughput

0.691

High

889407

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

889524

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

3

High-throughput

0.691

High

889422

RBM39
RNA-binding protein 39

2

20

High-throughput

0.687

High

889389

1433G
14-3-3 protein gamma

3

20

High-throughput

0.657

High

67820

SRRM4
Serine/arginine repetitive matrix protein 4

3

1

High-throughput

0.654

High

225264

HTSF1
17S U2 SnRNP complex component HTATSF1

1

20

High-throughput

0.647

High

484997

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

16

High-throughput

0.647

High

586251

ZEP1
Zinc finger protein 40

1

6

High-throughput

0.647

High

620208

NUCL
Nucleolin

1

11

High-throughput

0.647

High

794409

RBMX
RNA-binding motif protein, X chromosome

1

20

High-throughput

0.647

High

889380

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

20

High-throughput

0.647

High

889411

RLF
Zinc finger protein Rlf

1

5

High-throughput

0.647

High

889412

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

19

High-throughput

0.647

High

889416

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

18

Small-scale

0.647

High

889425

KIF14
Kinesin-like protein KIF14

1

11

High-throughput

0.647

High

889435

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

4

High-throughput

0.647

High

889436

SMBT2
Scm-like with four MBT domains protein 2

1

3

High-throughput

0.647

High

889449

ABCAD
ATP-binding cassette sub-family A member 13

1

1

High-throughput

0.647

High

889488

RBM15
RNA-binding protein 15

1

19

High-throughput

0.647

High

889489

MINT
Msx2-interacting protein

1

20

High-throughput

0.647

High

889499

UBL5
Ubiquitin-like protein 5

1

3

Small-scale

0.647

High

889507

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

1

4

High-throughput

0.647

High

889513

CDK12
Cyclin-dependent kinase 12

1

16

High-throughput

0.647

High

889497

DOCK9
Dedicator of cytokinesis protein 9

1

3

High-throughput

0.625

High

889426

SAFB1
Scaffold attachment factor B1

1

20

Small-scale

0.621

High

889532

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

9

High-throughput

0.619

High

425378

ISG15
Ubiquitin-like protein ISG15

1

5

High-throughput

0.618

High

303312

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

3

4

High-throughput

0.616

High

889386

KR107
Keratin-associated protein 10-7

3

8

High-throughput

0.616

High

889496

STK31
Serine/threonine-protein kinase 31

1

0

High-throughput

0.614

High

889451

ZCH18
Zinc finger CCCH domain-containing protein 18

3

18

High-throughput

0.612

High

889457

CLASR
CLK4-associating serine/arginine rich protein

3

9

High-throughput

0.600

High

889460

PR38A
Pre-mRNA-splicing factor 38A

2

1

High-throughput

0.594

High

164802

UN13B
Protein unc-13 homolog B

1

5

High-throughput

0.579

High

273503

DJC13
DnaJ homolog subfamily C member 13

1

5

High-throughput

0.579

High

889381

MYOM1
Myomesin-1

1

6

High-throughput

0.579

High

889441

DJC24
DnaJ homolog subfamily C member 24

1

2

High-throughput

0.579

High

889445

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

11

High-throughput

0.579

High

889448

PHLB2
Pleckstrin homology-like domain family B member 2

1

20

High-throughput

0.579

High

889452

MICU3
Calcium uptake protein 3, mitochondrial

1

1

High-throughput

0.579

High

889462

LIPB2
Liprin-beta-2

1

10

High-throughput

0.579

High

889511

RASLC
Ras-like protein family member 12

1

5

High-throughput

0.579

High

889516

ANFY1
Rabankyrin-5

1

3

High-throughput

0.579

High

889525

ZN148
Zinc finger protein 148

1

2

High-throughput

0.579

High

378964

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.578

High

889427

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

1

3

High-throughput

0.555

High

889474

SRS12
Serine/arginine-rich splicing factor 12

1

20

High-throughput

0.555

High

889491

SRSF8
Serine/arginine-rich splicing factor 8

1

14

High-throughput

0.555

High

889385

KR106
Keratin-associated protein 10-6

2

9

High-throughput

0.553

High

889468

LNX1
E3 ubiquitin-protein ligase LNX

2

11

High-throughput

0.553

High

889478

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

9

High-throughput

0.553

High

889382

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

10

High-throughput

0.536

High

391004

TRFL
Lactotransferrin

1

0

High-throughput

0.513

High

162504

ANM5
Protein arginine N-methyltransferase 5

1

8

High-throughput

0.508

High

245381

AT10A
Phospholipid-transporting ATPase VA

1

6

High-throughput

0.501

High

256802

H2B1K
Histone H2B type 1-K

1

5

High-throughput

0.501

High

282453

KTNA1
Katanin p60 ATPase-containing subunit A1

1

11

High-throughput

0.501

High

285830

SF3B1
Splicing factor 3B subunit 1

1

5

High-throughput

0.501

High

330429

LC7L3
Luc7-like protein 3

1

6

Small-scale

0.501

High

385557

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.501

High

445781

ENOA
Alpha-enolase

1

2

High-throughput

0.501

High

446773

NPM
Nucleophosmin

1

5

High-throughput

0.501

High

552534

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.501

High

633889

ATP4A
Potassium-transporting ATPase alpha chain 1

1

5

High-throughput

0.501

High

637863

NF1
Neurofibromin

1

6

High-throughput

0.501

High

644178

RS4Y1
Small ribosomal subunit protein eS4, Y isoform 1

1

1

High-throughput

0.501

High

731083

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.501

High

837452

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.501

High

859149

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.501

High

889390

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

14

High-throughput

0.501

High

889393

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

4

High-throughput

0.501

High

889395

PRKDC
DNA-dependent protein kinase catalytic subunit

1

4

High-throughput

0.501

High

889397

CENPE
Centromere-associated protein E

1

9

High-throughput

0.501

High

889398

KIF23
Kinesin-like protein KIF23

1

10

High-throughput

0.501

High

889404

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

5

High-throughput

0.501

High

889415

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

6

High-throughput

0.501

High

889418

CUL3
Cullin-3

1

12

High-throughput

0.501

High

889423

FAT1
Protocadherin Fat 1

1

5

High-throughput

0.501

High

889434

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

20

High-throughput

0.501

High

889447

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

11

High-throughput

0.501

High

889455

SRRM1
Serine/arginine repetitive matrix protein 1

1

16

High-throughput

0.501

High

889472

GEMI5
Gem-associated protein 5

1

13

High-throughput

0.501

High

889476

PHF3
PHD finger protein 3

1

4

High-throughput

0.501

High

889484

YTDC1
YTH domain-containing protein 1

1

6

High-throughput

0.501

High

889486

PRPK
EKC/KEOPS complex subunit TP53RK

1

7

High-throughput

0.501

High

889495

SSBP3
Single-stranded DNA-binding protein 3

1

6

High-throughput

0.501

High

889498

CRNL1
Crooked neck-like protein 1

1

10

High-throughput

0.501

High

889501

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

3

High-throughput

0.501

High

889505

RD21L
Double-strand-break repair protein rad21-like protein 1

1

1

High-throughput

0.501

High

889518

ZO2
Tight junction protein 2

1

4

High-throughput

0.501

High

889522

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.501

High

889523

CTND2
Catenin delta-2

1

13

High-throughput

0.501

High

889527

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

2

High-throughput

0.501

High

889528

TR150
Thyroid hormone receptor-associated protein 3

1

20

High-throughput

0.501

High

229984

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

7

High-throughput

0.489

High

665876

AKAP5
A-kinase anchor protein 5

1

1

High-throughput

0.489

High

889388

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

3

High-throughput

0.489

High

889405

KLC1
Kinesin light chain 1

1

6

High-throughput

0.489

High

889438

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

1

High-throughput

0.489

High

889470

BPIB1
BPI fold-containing family B member 1

1

1

High-throughput

0.489

High

889482

SAHH3
Adenosylhomocysteinase 3

1

7

High-throughput

0.489

High

889508

BPIA1
BPI fold-containing family A member 1

1

1

High-throughput

0.489

High

889520

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

1

1

High-throughput

0.489

High

889458

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.486

High

278274

NCOR1
Nuclear receptor corepressor 1

1

15

Small-scale

0.481

High

889463

TDRD9
ATP-dependent RNA helicase TDRD9

1

11

High-throughput

0.481

High

889493

DDX23
Probable ATP-dependent RNA helicase DDX23

1

9

High-throughput

0.481

High

889509

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

2

High-throughput

0.481

High

889510

BCLF1
Bcl-2-associated transcription factor 1

1

15

Small-scale

0.481

High

437123

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.480

High

716409

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.480

High

889384

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.480

High

889408

SLFN5
Schlafen family member 5

1

0

High-throughput

0.480

High

889409

ELP6
Elongator complex protein 6

1

0

High-throughput

0.480

High

889446

MYCPP
C-myc promoter-binding protein

1

0

High-throughput

0.480

High

889475

IP6K1
Inositol hexakisphosphate kinase 1

1

0

High-throughput

0.480

High

889521

DBR1
Lariat debranching enzyme

1

0

High-throughput

0.480

High

347578

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

704725

ERCC5
DNA excision repair protein ERCC-5

1

11

High-throughput

0.479

High

889379

MECP2
Methyl-CpG-binding protein 2

1

6

High-throughput

0.479

High

889387

PSME3
Proteasome activator complex subunit 3

1

2

High-throughput

0.479

High

889392

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

889402

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

889419

TF2H3
General transcription factor IIH subunit 3

1

2

High-throughput

0.479

High

889432

Q59FZ7
DNA excision repair protein ERCC-5

1

11

High-throughput

0.479

High

889454

CUL9
Cullin-9

1

4

High-throughput

0.479

High

889494

HIRP3
HIRA-interacting protein 3

1

4

High-throughput

0.479

High

889519

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

889485

ZN830
Zinc finger protein 830

1

0

High-throughput

0.460

High

186231

GRM6
Metabotropic glutamate receptor 6

1

1

High-throughput

0.457

High

188835

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.457

High

215708

COCH
Cochlin

1

1

High-throughput

0.457

High

295425

SPI2
Serpin I2

1

5

High-throughput

0.457

High

409193

ARLY
Argininosuccinate lyase

1

1

High-throughput

0.457

High

473675

ITA5
Integrin alpha-5

1

1

High-throughput

0.457

High

844179

ECE1
Endothelin-converting enzyme 1

1

1

High-throughput

0.457

High

889376

NU153
Nuclear pore complex protein Nup153

1

15

High-throughput

0.457

High

889399

DSC2
Desmocollin-2

1

4

High-throughput

0.457

High

889410

DPYD
Dihydropyrimidine dehydrogenase [NADP(+)]

1

2

High-throughput

0.457

High

889420

CKAP5
Cytoskeleton-associated protein 5

1

6

High-throughput

0.457

High

889421

MAP7
Ensconsin

1

19

High-throughput

0.457

High

889429

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

2

High-throughput

0.457

High

889430

SHRM1
Protein Shroom1

1

2

High-throughput

0.457

High

889442

CWC27
Spliceosome-associated protein CWC27 homolog

1

1

High-throughput

0.457

High

889464

PPHLN
Periphilin-1

1

2

High-throughput

0.457

High

889465

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.457

High

889467

GSDMB
Gasdermin-B

1

1

High-throughput

0.457

High

889469

CF251
Cilia- and flagella-associated protein 251

1

6

High-throughput

0.457

High

889471

PK1L1
Polycystin-1-like protein 1

1

1

High-throughput

0.457

High

889473

FBF1
Fas-binding factor 1

1

20

High-throughput

0.457

High

889490

ACOX2
Peroxisomal acyl-coenzyme A oxidase 2

1

2

High-throughput

0.457

High

889500

ASXL3
Putative Polycomb group protein ASXL3

1

19

High-throughput

0.457

High

889502

CAD23
Cadherin-23

1

5

High-throughput

0.457

High

889503

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

12

High-throughput

0.457

High

889512

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

1

5

High-throughput

0.457

High

889514

HPBP1
Hsp70-binding protein 1

1

8

High-throughput

0.457

High

889515

ARHGC
Rho guanine nucleotide exchange factor 12

1

4

High-throughput

0.457

High

889526

ICE1
Little elongation complex subunit 1

1

2

High-throughput

0.457

High

889531

MTCL1
Microtubule cross-linking factor 1

1

19

High-throughput

0.457

High

889533

TLN2
Talin-2

1

19

High-throughput

0.457

High

686029

RL13
Large ribosomal subunit protein eL13

1

3

High-throughput

0.445

High

744639

TF2H1
General transcription factor IIH subunit 1

1

3

High-throughput

0.437

High

889400

ENL
Protein ENL

1

16

High-throughput

0.437

High

889492

ATGA1
Autophagy-related protein 101

1

2

High-throughput

0.437

High

889504

PININ
Pinin

1

3

High-throughput

0.437

High

889534

TNPO3
Transportin-3

1

10

Small-scale

0.437

High

391781

PRB2
Basic salivary proline-rich protein 2

1

3

High-throughput

0.407

High

611032

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

6

Small-scale

0.407

High

889401

PRB3
Basic salivary proline-rich protein 3

1

5

High-throughput

0.407

High

889530

LC7L2
Putative RNA-binding protein Luc7-like 2

1

7

High-throughput

0.407

High

889383

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

1

0

High-throughput

0.282

High

889477

SYMPK
Symplekin

1

0

High-throughput

0.279

Low

889479

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.279

Low

889377

PSN2
Presenilin-2

1

0

High-throughput

0.269

Low

245759

EREP2
Protein ENTREP2

1

0

High-throughput

0.261

Low

294623

ZMY10
Zinc finger MYND domain-containing protein 10

1

0

High-throughput

0.261

Low

406965

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.261

Low

889378

HNMT
Histamine N-methyltransferase

1

0

High-throughput

0.261

Low

889424

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.261

Low

889431

ERFE
Erythroferrone

1

0

High-throughput

0.261

Low

889433

S35D3
Solute carrier family 35 member D3

1

0

High-throughput

0.261

Low

889437

SCAR3
Scavenger receptor class A member 3

1

0

High-throughput

0.261

Low

889439

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.261

Low

889440

CA094
Uncharacterized protein C1orf94

1

0

High-throughput

0.261

Low

889443

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.261

Low

889444

CF20D
Protein CFAP20DC

1

0

High-throughput

0.261

Low

889450

FHI2B
FHF complex subunit HOOK-interacting protein 2B

1

0

High-throughput

0.261

Low

889453

SAM9L
Sterile alpha motif domain-containing protein 9-like

1

0

High-throughput

0.261

Low

889456

TEX11
Testis-expressed protein 11

1

0

High-throughput

0.261

Low

889459

SVOP
Synaptic vesicle 2-related protein

1

0

High-throughput

0.261

Low

889466

LINES
Protein Lines homolog 1

1

0

High-throughput

0.261

Low

889480

MTBP
Mdm2-binding protein

1

0

High-throughput

0.261

Low

889481

CEP95
Centrosomal protein of 95 kDa

1

0

High-throughput

0.261

Low

889483

PLAT5
Phospholipase A and acyltransferase 5

1

0

High-throughput

0.261

Low

889506

CDCP1
CUB domain-containing protein 1

1

0

High-throughput

0.261

Low

889517

REV1
DNA repair protein REV1

1

0

High-throughput

0.261

Low

889529

VWA7
von Willebrand factor A domain-containing protein 7

1

0

High-throughput

0.261

Low

889535

CP46A
Cholesterol 24-hydroxylase

1

0

High-throughput

0.261

Low

889461

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025