HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	36508830, 35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 248
+	Hs
		227346 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25
+	Hs
		227347 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		227348 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		227267 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		226375 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		228678 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP3_HUMAN (8-203): 1.09e-33: 129: 16.18
+	Hs
		227170 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		227642 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAP1L_HUMAN (17-148): 9.11e-22: 95.4: 18.80
+	Hs
		227585 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Hs
		227354 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP4_HUMAN (118-200): 2.19e-13: 71.2: 16.67
+	Hs
		227193 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TIAR_HUMAN (113-202): 2.85e-10: 61.5: 12.63
+	Hs
		226635 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TIA1_HUMAN (115-203): 6.11e-10: 60.4: 11.70
+	Hs
		312595 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		312586 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		475007 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		312462 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		1031383 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PABP4_HUMAN (118-200): 2.19e-13: 71.2: 16.67
+	Hs
		312572 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		312493 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		TIA1_HUMAN (115-203): 6.11e-10: 60.4: 11.70
+	Hs
		475288 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67