Protein: ORC4
Origin recognition complex subunit 4

Gene: ORC4
Organism: Homo sapiens
Interactions: 119
UniProt ID: O43929

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000781 - chromosome, telomeric region
GO:0000808 - origin recognition complex
GO:0003688 - DNA replication origin binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

231474

ORC2
Origin recognition complex subunit 2

12

13

Small-scale

0.979

High

230854

ORC5
Origin recognition complex subunit 5

7

19

Small-scale

0.953

High

231473

ORC1
Origin recognition complex subunit 1

6

13

Small-scale

0.942

High

231526

ORC3
Origin recognition complex subunit 3

6

13

Small-scale

0.935

High

231446

MCM3
DNA replication licensing factor MCM3

2

20

Small-scale

0.793

High

231536

ORC6
Origin recognition complex subunit 6

4

6

Small-scale

0.699

High

231452

MCM7
DNA replication licensing factor MCM7

1

20

High-throughput

0.692

High

231499

LACC1
Purine nucleoside phosphorylase LACC1

3

0

High-throughput

0.629

High

231451

MCM4
DNA replication licensing factor MCM4

1

19

Small-scale

0.621

High

231462

MCM2
DNA replication licensing factor MCM2

1

20

Small-scale

0.621

High

231478

MCM6
DNA replication licensing factor MCM6

1

20

Small-scale

0.621

High

231528

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

2

2

Small-scale

0.611

High

231444

RFA2
Replication protein A 32 kDa subunit

2

2

Small-scale

0.586

High

231433

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

231496

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

High-throughput

0.557

High

231443

ITF2
Transcription factor 4

1

0

High-throughput

0.549

High

231445

CCND1
G1/S-specific cyclin-D1

1

9

High-throughput

0.536

High

231458

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

High-throughput

0.536

High

231495

MCM10
Protein MCM10 homolog

1

4

High-throughput

0.536

High

231438

LAMP1
Lysosome-associated membrane glycoprotein 1

1

3

High-throughput

0.536

High

231469

AKA12
A-kinase anchor protein 12

1

1

High-throughput

0.536

High

231471

FOXL1
Forkhead box protein L1

1

3

High-throughput

0.536

High

231487

H2B2E
Histone H2B type 2-E

1

5

High-throughput

0.536

High

231517

TSNAX
Translin-associated protein X

1

1

High-throughput

0.536

High

231523

SCN3B
Sodium channel regulatory subunit beta-3

1

2

High-throughput

0.536

High

231524

PD1L1
Programmed cell death 1 ligand 1

1

3

High-throughput

0.536

High

231459

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

231482

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

231491

PARM1
Prostate androgen-regulated mucin-like protein 1

1

0

High-throughput

0.513

High

231498

PDPN
Podoplanin

1

0

High-throughput

0.513

High

231501

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

231504

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

231516

P2RX4
P2X purinoceptor 4

1

0

High-throughput

0.513

High

231435

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

62076

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

1

High-throughput

0.489

High

231425

ICOSL
ICOS ligand

1

4

High-throughput

0.489

High

231426

NCTR1
Natural cytotoxicity triggering receptor 1

1

1

High-throughput

0.489

High

231428

VAMP5
Vesicle-associated membrane protein 5

1

6

High-throughput

0.489

High

231429

TNF6B
Tumor necrosis factor receptor superfamily member 6B

1

6

High-throughput

0.489

High

231447

TNR5
Tumor necrosis factor receptor superfamily member 5

1

7

High-throughput

0.489

High

231457

OX2G
OX-2 membrane glycoprotein

1

4

High-throughput

0.489

High

231467

DLK1
Protein delta homolog 1

1

1

High-throughput

0.489

High

231483

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.489

High

231488

MICA
MHC class I polypeptide-related sequence A

1

1

High-throughput

0.489

High

231489

KLC3
Kinesin light chain 3

1

1

High-throughput

0.489

High

231492

VSTM1
V-set and transmembrane domain-containing protein 1

1

1

High-throughput

0.489

High

231520

C1QR1
Complement component C1q receptor

1

1

High-throughput

0.489

High

231532

CAH14
Carbonic anhydrase 14

1

1

High-throughput

0.489

High

231456

MLH1
DNA mismatch repair protein Mlh1

1

2

High-throughput

0.481

High

231463

IMA5
Importin subunit alpha-5

1

3

High-throughput

0.481

High

231472

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.481

High

231509

FBX25
F-box only protein 25

1

1

High-throughput

0.481

High

231531

MTUS1
Microtubule-associated tumor suppressor 1

1

3

High-throughput

0.481

High

227265

SPOP
Speckle-type POZ protein

1

6

High-throughput

0.479

High

231423

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

231427

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

231439

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

231440

XRCC5
X-ray repair cross-complementing protein 5

1

3

Small-scale

0.479

High

231448

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

231454

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

231455

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

231460

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

231466

H31
Histone H3.1

1

3

High-throughput

0.479

High

231468

H33
Histone H3.3

1

3

High-throughput

0.479

High

231475

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.479

High

231480

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

231481

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.479

High

231497

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

231515

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.479

High

231527

DBF4A
Protein DBF4 homolog A

1

1

Small-scale

0.479

High

231512

FBXL8
F-box/LRR-repeat protein 8

1

0

High-throughput

0.460

High

231522

FBX6
F-box only protein 6

1

0

High-throughput

0.460

High

231530

FBXL5
F-box/LRR-repeat protein 5

1

0

High-throughput

0.460

High

231534

KLH20
Kelch-like protein 20

1

0

Small-scale

0.460

High

231434

CATA
Catalase

1

0

High-throughput

0.458

High

231476

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

0

High-throughput

0.458

High

231479

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

231508

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

231510

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.458

High

231503

S35F6
Solute carrier family 35 member F6

1

1

High-throughput

0.445

High

231521

S17A5
Sialin

1

2

High-throughput

0.445

High

231441

CCL2
C-C motif chemokine 2

1

1

Small-scale

0.437

High

231493

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

231518

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

231430

CYB5
Cytochrome b5

1

0

High-throughput

0.426

High

231432

GLPA
Glycophorin-A

1

0

High-throughput

0.426

High

231461

NRAM2
Natural resistance-associated macrophage protein 2

1

0

High-throughput

0.426

High

231477

LRC32
Transforming growth factor beta activator LRRC32

1

0

High-throughput

0.426

High

231494

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.426

High

231535

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

0

High-throughput

0.426

High

231465

H4
Histone H4

1

5

High-throughput

0.408

High

231486

H31T
Histone H3.1t

1

3

High-throughput

0.408

High

231424

SCN2B
Sodium channel regulatory subunit beta-2

1

4

High-throughput

0.407

High

231450

CD80
T-lymphocyte activation antigen CD80

1

4

High-throughput

0.407

High

231464

VMAT1
Chromaffin granule amine transporter

1

5

High-throughput

0.407

High

231470

VMAT2
Synaptic vesicular amine transporter

1

5

High-throughput

0.407

High

231484

CD226
CD226 antigen

1

5

High-throughput

0.407

High

231485

VACHT
Vesicular acetylcholine transporter

1

5

High-throughput

0.407

High

231502

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

231505

S15A4
Solute carrier family 15 member 4

1

1

High-throughput

0.407

High

231507

MFSD8
Major facilitator superfamily domain-containing protein 8

1

1

High-throughput

0.407

High

231513

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

2

High-throughput

0.407

High

231525

VGLU2
Vesicular glutamate transporter 2

1

2

High-throughput

0.407

High

231442

PVR
Poliovirus receptor

2

0

High-throughput

0.313

High

231537

NPTN
Neuroplastin

2

0

High-throughput

0.313

High

231511

RDH5
Retinol dehydrogenase 5

1

0

High-throughput

0.292

High

226294

SNG1
Synaptogyrin-1

1

0

High-throughput

0.279

Low

231431

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.279

Low

231436

ITA5
Integrin alpha-5

1

0

High-throughput

0.279

Low

231437

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.279

Low

231449

IL1R2
Interleukin-1 receptor type 2

1

0

High-throughput

0.279

Low

231453

SDC2
Syndecan-2

1

0

High-throughput

0.279

Low

231490

TM154
Transmembrane protein 154

1

0

High-throughput

0.279

Low

231506

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.279

Low

231514

TXD15
Thioredoxin domain-containing protein 15

1

0

High-throughput

0.279

Low

231519

SPRNG
SREBP regulating gene protein

1

0

High-throughput

0.279

Low

231529

FLOWR
Calcium channel flower homolog

1

0

High-throughput

0.279

Low

231500

MFS6L
Major facilitator superfamily domain-containing protein 6-like

1

0

High-throughput

0.232

Low

231533

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025