HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ACACA (Q13085)
Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha)
Gene: ACACA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 2346
+	Hs
		475692 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ACACA_HUMAN (1-2346): 0: 3256: 100.00
+	At
		1091640 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ACC1_ARATH (101-2341): 0: 2474: 38.13
+	At
		95494 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ACC2_ARATH (101-2341): 0: 2452: 37.93
+	Hs
		226252 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCCA_HUMAN (65-819): 0: 680: 25.19
+	Hs
		228431 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MCCA_HUMAN (88-830): 0: 675: 25.20
+	Sc
		424289 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PYR1_YEAST (133-1122): 0: 805: 12.52
+	Hs
		398217 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PCCA_HUMAN (65-819): 0: 680: 25.19
+	Hs
		476238 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MCCA_HUMAN (88-830): 0: 675: 25.20
+	At
		1091678 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		MCCA_ARATH (78-819): 0: 627: 26.76
+	At
		138699 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ACCC_ARATH (52-625): 0: 596: 29.47
+	Hs
		226587 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PYR1_HUMAN (681-1026): 5.11e-41: 169: 10.94
+	Hs
		226370 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PYC_HUMAN (699-819): 4.03e-16: 87.6: 17.97
+	At
		1091692 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CARB_ARATH (609-1191): 4.53e-37: 156: 12.46
+	Hs
		475387 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CPSM_HUMAN (637-1027): 1.42e-35: 151: 9.59
+	Hs
		475285 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PYC_HUMAN (699-819): 4.03e-16: 87.6: 17.97