Protein: KLHL3
Kelch-like protein 3

Gene: KLHL3
Organism: Homo sapiens
Interactions: 44
UniProt ID: Q9UH77

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005198 - structural molecule activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005856 - cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1114569

CUL3
Cullin-3

18

20

Small-scale

0.987

High

1121551

KEAP1
Kelch-like ECH-associated protein 1

4

19

High-throughput

0.895

High

1199050

KLH12
Kelch-like protein 12

4

19

High-throughput

0.895

High

329117

KLHL2
Kelch-like protein 2

4

19

High-throughput

0.894

High

1394709

WNK4
Serine/threonine-protein kinase WNK4

11

10

Small-scale

0.758

High

1459688

KLHL3
Kelch-like protein 3

2

19

Small-scale

0.757

High

1433320

WNK1
Serine/threonine-protein kinase WNK1

6

15

Small-scale

0.730

High

1247782

KLH17
Kelch-like protein 17

1

19

High-throughput

0.691

High

1459082

FXL17
F-box/LRR-repeat protein 17

1

16

High-throughput

0.691

High

1418964

WNK3
Serine/threonine-protein kinase WNK3

4

9

Small-scale

0.686

High

1200023

KLH26
Kelch-like protein 26

1

20

High-throughput

0.618

High

1115120

CUL4A
Cullin-4A

1

20

High-throughput

0.618

High

164659

TNPO2
Transportin-2

2

2

High-throughput

0.606

High

984010

RBX1
E3 ubiquitin-protein ligase RBX1

2

8

Small-scale

0.595

High

1459689

WNK2
Serine/threonine-protein kinase WNK2

2

12

Small-scale

0.584

High

177073

CE290
Centrosomal protein of 290 kDa

1

5

High-throughput

0.536

High

977851

ACTA
Actin, aortic smooth muscle

1

8

High-throughput

0.536

High

1308608

NUDC3
NudC domain-containing protein 3

1

20

High-throughput

0.536

High

167414

KLF11
Krueppel-like factor 11

1

2

High-throughput

0.515

High

274796

DNJB6
DnaJ homolog subfamily B member 6

1

9

High-throughput

0.515

High

374989

RASH
GTPase HRas

1

1

High-throughput

0.515

High

442513

GELS
Gelsolin

1

1

High-throughput

0.515

High

937127

CASP6
Caspase-6

1

3

High-throughput

0.515

High

94339

D6R9G5
Kelch like family member 2

1

18

High-throughput

0.514

High

605836

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

4

Small-scale

0.501

High

728465

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.501

High

957228

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

5

Small-scale

0.501

High

1062412

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

1

Small-scale

0.501

High

50377

PXDNL
Probable oxidoreductase PXDNL

1

1

High-throughput

0.489

High

336209

TNF6B
Tumor necrosis factor receptor superfamily member 6B

1

1

High-throughput

0.489

High

339001

CBX6
Chromobox protein homolog 6

1

3

High-throughput

0.489

High

404523

GCR
Glucocorticoid receptor

1

4

High-throughput

0.479

High

971243

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

1108257

SQSTM
Sequestosome-1

1

7

Small-scale

0.479

High

562468

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.470

High

650472

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.470

High

933545

S12A3
Solute carrier family 12 member 3

1

0

Small-scale

0.458

High

942287

CLD8
Claudin-8

1

0

Small-scale

0.458

High

1136878

MO4L2
Mortality factor 4-like protein 2

1

1

High-throughput

0.439

High

1315389

CF206
Cilia- and flagella-associated protein 206

1

1

High-throughput

0.439

High

873127

SOX9
Transcription factor SOX-9

1

6

Small-scale

0.437

High

251334

PSPN
Persephin

1

0

High-throughput

0.279

Low

1213369

RM02
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025