HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35244772, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031072 - heat shock protein binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 457
+	Hs
		227216 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		118648 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		227443 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		226646 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		1317095 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		FKBPL_HUMAN (133-414): 4.04e-51: 178: 25.70
+	Hs
		476533 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FKBPL_HUMAN (133-414): 4.04e-51: 178: 25.70
+	Hs
		475754 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23