Protein: KLHL6
Kelch-like protein 6

Gene: KLHL6
Organism: Homo sapiens
Interactions: 27
UniProt ID: Q8WZ60

Gene Ontology (top 5):
GO:0002467 - germinal center formation
GO:0005737 - cytoplasm
GO:0009617 - response to bacterium
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1113862

CUL3
Cullin-3

3

20

Small-scale

0.834

High

1312877

KLHL7
Kelch-like protein 7

2

20

High-throughput

0.811

High

1308563

NUDC3
NudC domain-containing protein 3

3

20

High-throughput

0.667

High

242440

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.665

High

1361976

RC3H2
Roquin-2

4

1

Small-scale

0.650

High

1361974

KLHL6
Kelch-like protein 6

1

20

Small-scale

0.647

High

464280

FUMH
Fumarate hydratase, mitochondrial

2

1

High-throughput

0.606

High

1118937

BYST
Bystin

2

1

High-throughput

0.606

High

837754

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

2

0

High-throughput

0.580

High

1193548

CRY2
Cryptochrome-2

2

0

High-throughput

0.580

High

1361978

PPR1B
Protein phosphatase 1 regulatory subunit 1B

1

0

High-throughput

0.549

High

1156165

ZYX
Zyxin

1

3

High-throughput

0.536

High

667953

CDK2
Cyclin-dependent kinase 2

1

0

Small-scale

0.529

High

1361980

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.518

High

728352

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

High-throughput

0.506

High

1106631

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.506

High

739011

ELF1
ETS-related transcription factor Elf-1

1

4

High-throughput

0.489

High

1361977

PDLI7
PDZ and LIM domain protein 7

1

5

High-throughput

0.489

High

461767

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

468653

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

1361979

NUDC
Nuclear migration protein nudC

1

20

High-throughput

0.479

High

625527

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.437

High

997897

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.437

High

1141835

EEA1
Early endosome antigen 1

1

5

High-throughput

0.437

High

1337823

CSK23
Casein kinase II subunit alpha 3

1

4

High-throughput

0.437

High

1361975

DHRS4
Dehydrogenase/reductase SDR family member 4

2

0

High-throughput

0.328

High


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Last updated: 11Aug2025