HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: DX39B (Q13838)
Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein)
Gene: DDX39B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	32929329, 35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 428
+	Hs
		228251 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DDX17_HUMAN (6-423): 6.26e-132: 398: 25.06
+	Hs
		226462 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DDX5_HUMAN (6-421): 4.17e-133: 397: 25.00
+	Hs
		117064 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DX39A_HUMAN (1-428): 3.89e-128: 378: 89.95
+	Hs
		133780 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DDX3X_HUMAN (3-423): 4.76e-124: 375: 27.84
+	Hs
		226720 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IF4A3_HUMAN (52-415): 7.9e-81: 256: 38.36
+	Hs
		117178 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		DX39A_HUMAN (1-428): 3.89e-128: 378: 89.95
+	Hs
		134115 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		DDX3X_HUMAN (3-423): 4.76e-124: 375: 27.84
+	Hs
		226570 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DDX6_HUMAN (30-426): 2.5e-75: 244: 35.68
+	Hs
		312636 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		DDX17_HUMAN (6-423): 6.26e-132: 398: 25.06
+	Hs
		133805 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		DDX3X_HUMAN (3-423): 4.76e-124: 375: 27.84
+	Hs
		757673 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		IF4A3_HUMAN (52-415): 7.9e-81: 256: 38.36
+	Hs
		476139 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DDX17_HUMAN (6-423): 6.26e-132: 398: 25.06
+	At
		1091701 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		RH15_ARATH (25-425): 5.59e-126: 372: 73.57
+	Sc
		477283 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		DHH1_YEAST (47-426): 4.5e-79: 254: 38.32
+	At
		1091993 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		IF4A3_ARATH (52-418): 3.27e-79: 252: 39.40
+	At
		783417 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		IF4A1_ARATH (38-418): 2.88e-78: 249: 38.74
+	At
		783425 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		IF4A2_ARATH (38-418): 1.18e-77: 248: 39.01