Protein: KLHL8
Kelch-like protein 8

Gene: KLHL8, kel-8
Organism: Caenorhabditis elegans
Interactions: 57
UniProt ID: G5ED84

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0014069 - postsynaptic density
GO:0016567 - protein ubiquitination
GO:0031463 - Cul3-RING ubiquitin ligase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

111541

CUL3
Cullin-3

1

20

Small-scale

0.713

High

111524

PSA1
Proteasome subunit alpha type-1

2

1

High-throughput

0.613

High

111553

PSA2
Proteasome subunit alpha type-2

2

1

High-throughput

0.613

High

111556

PSA7
Proteasome subunit alpha type-7

2

1

High-throughput

0.613

High

111562

Q9U2T9
Intersectin-1

2

4

Small-scale

0.595

High

111544

Q18776
BTB domain-containing protein

1

3

High-throughput

0.590

High

111563

Q9U2Z5
Osteoclast-stimulating factor 1

1

4

High-throughput

0.590

High

111537

PSA3
Proteasome subunit alpha type-3

2

1

High-throughput

0.576

High

111557

PSA5
Proteasome subunit alpha type-5

2

1

High-throughput

0.576

High

111540

ARF12
ADP-ribosylation factor 1-like 2

2

0

Small-scale

0.565

High

111527

PSB1
Proteasome subunit beta type-1

2

0

High-throughput

0.551

High

109063

G4RZC8
PID domain-containing protein

1

6

High-throughput

0.508

High

111517

G5EG39
Skp1-related protein

1

4

High-throughput

0.457

High

111520

CDC37
Probable Hsp90 co-chaperone cdc37

1

1

High-throughput

0.457

High

111530

MPK1
Mitogen-activated protein kinase mpk-1

1

2

High-throughput

0.457

High

111531

SMA3
Dwarfin sma-3

1

1

High-throughput

0.457

High

111536

RAPSN
43 kDa receptor-associated protein of the synapse homolog

1

4

High-throughput

0.457

High

111543

PMK1
Mitogen-activated protein kinase pmk-1

1

3

High-throughput

0.457

High

111548

MKK4
MAP kinase kinase mkk-4

1

10

High-throughput

0.457

High

111549

Q20660
SHSP domain-containing protein

1

3

High-throughput

0.457

High

111550

MEK1
Dual specificity mitogen-activated protein kinase kinase mek-1

1

7

High-throughput

0.457

High

111560

Q9NGT3
Mitotic spindle assembly checkpoint protein MAD2A

1

3

High-throughput

0.457

High

111566

Q9XXI4
Arrestin C-terminal-like domain-containing protein

1

3

High-throughput

0.457

High

111518

H2KZ17
DiSHevelled related

1

10

High-throughput

0.439

High

111522

O17066
Snurportin-1

1

0

High-throughput

0.438

High

111523

RAN
GTP-binding nuclear protein ran-1

1

0

High-throughput

0.438

High

111534

UFC1
Ubiquitin-fold modifier-conjugating enzyme 1

1

0

High-throughput

0.438

High

111551

Q22020
Peroxiredoxin-like 2A

1

0

High-throughput

0.438

High

111554

Q93716
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.438

High

73205

B1Q240
DiSHevelled related

1

11

High-throughput

0.417

High

111514

G5EDL3
Aurora kinase

1

6

High-throughput

0.417

High

111515

G5EEZ4
WD repeat-containing protein 55

1

4

High-throughput

0.417

High

111516

G5EFD7
WD_REPEATS_REGION domain-containing protein

1

3

High-throughput

0.417

High

111526

O44608
3-hydroxyacyl-CoA dehydrogenase

1

1

High-throughput

0.417

High

111533

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

High-throughput

0.417

High

111538

Q09584
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.417

High

111545

MAAI
Probable maleylacetoacetate isomerase

1

3

High-throughput

0.417

High

111547

Q20308
Nicotinamide N-methyltransferase

1

2

High-throughput

0.417

High

111552

WDR4
tRNA

1

1

High-throughput

0.417

High

111559

Q9N4H6
maleylacetoacetate isomerase

1

3

High-throughput

0.417

High

111565

Q9XXA2
Calponin homology domain-containing protein

1

1

High-throughput

0.417

High

111567

CLA1
Protein clarinet

1

4

High-throughput

0.417

High

111532

ATPB
ATP synthase subunit beta, mitochondrial

1

0

Small-scale

0.265

Low

111555

UFSP
Ufm1-specific protease

1

0

Small-scale

0.251

Low

111089

G5ECR7
RNA polymerase II transcription factor SIII p18 subunit

1

0

High-throughput

0.238

Low

111519

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.238

Low

111521

FABP7
Fatty acid-binding protein homolog 7

1

0

High-throughput

0.238

Low

111525

O44606

1

0

High-throughput

0.238

Low

111528

YLZ6
Putative esterase F42H10.6

1

0

High-throughput

0.238

Low

111529

TPPC3
Trafficking protein particle complex subunit 3 homolog

1

0

High-throughput

0.238

Low

111535

T23O
Tryptophan 2,3-dioxygenase

1

0

High-throughput

0.238

Low

111539

KARG1
Probable arginine kinase F46H5.3

1

0

High-throughput

0.238

Low

111542

GNA1
Glucosamine 6-phosphate N-acetyltransferase

1

0

High-throughput

0.238

Low

111546

RPAB3
Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.238

Low

111558

Q9N3H9
protein-disulfide reductase

1

0

High-throughput

0.238

Low

111561

Q9U2E4
Beta,beta-carotene 9',10'-oxygenase

1

0

High-throughput

0.238

Low

111564

OTUBL
Ubiquitin thioesterase otubain-like

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025