HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: FKBP8 (Q14318)
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
Gene: FKBP8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001933 - negative regulation of protein phosphorylation GO:0005739 - mitochondrion GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0070585 - protein localization to mitochondrion
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 412
+	Hs
		118648 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AIP_HUMAN (97-369): 4.45e-54: 184: 18.94
+	Hs
		227216 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18
+	Hs
		226646 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00
+	Hs
		227369 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21
+	Hs
		475754 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00
+	Hs
		1317095 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		FKBPL_HUMAN (8-369): 7.94e-52: 178: 22.43
+	Sc
		477102 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		STI1_YEAST (221-371): 6.12e-25: 108: 19.21
+	Hs
		476533 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FKBPL_HUMAN (8-369): 7.94e-52: 178: 22.43
+	Hs
		475662 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SPAG1_HUMAN (225-336): 6.7e-16: 82.1: 20.54