HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: U5S1 (Q15029)
116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)
Gene: EFTUD2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016607 - nuclear speck
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 972
+	Hs
		1064465 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		U5S1_HUMAN (1-972): 0: 1062: 100.00
+	Hs
		226394 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EF2_HUMAN (111-957): 0: 915: 38.16
+	Hs
		312464 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		EF2_HUMAN (111-957): 0: 915: 38.16
+	At
		1092144 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CLO_ARATH (1-972): 0: 998: 60.99
+	At
		98384 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		GFL_ARATH (1-972): 0: 970: 59.98
+	Sc
		477174 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		EF2_YEAST (111-957): 0: 879: 36.04
+	Hs
		475296 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		EF2_HUMAN (111-957): 0: 915: 38.16
+	At
		97441 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		F4JB05_ARATH (132-957): 0: 874: 36.35
+	Hs
		228429 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EFGM_HUMAN (107-932): 0: 585: 19.64
+	At
		1092328 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		EFGC_ARATH (127-924): 0: 559: 19.90
+	At
		1091966 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		EFGM1_ARATH (102-925): 0: 558: 18.61