HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 538
+	Hs
		227671 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR44_HUMAN (53-281): 4.14e-54: 198: 24.46
+	Hs
		226765 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LIS1_HUMAN (104-423): 9.57e-53: 186: 9.65
+	Hs
		228868 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLE1_HUMAN (2-135): 8.57e-34: 135: 18.38
+	Hs
		227617 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SMU1_HUMAN (179-320): 3.28e-21: 99: 13.79
+	Hs
		228315 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		228623 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR33_HUMAN (198-342): 2.09e-17: 88.1: 10.67
+	Hs
		228276 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Sc
		477285 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		SWD1_YEAST (1-356): 1.48e-77: 252: 30.08
+	Hs
		1219356 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		475165 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		WDR83_HUMAN (1-327): 4.72e-39: 146: 20.61
+	Hs
		1281514 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	At
		187391 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		O22826_ARATH (179-479): 1.1e-32: 129: 12.16
+	Hs
		475845 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SMU1_HUMAN (179-320): 3.28e-21: 99: 13.79
+	Hs
		476181 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		476334 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR33_HUMAN (198-342): 2.09e-17: 88.1: 10.67
+	Hs
		476151 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41