Protein: ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8)

Gene: ZMYD8, ZMYND8
Organism: Homo sapiens
Interactions: 204
UniProt ID: Q9ULU4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000724 - double-strand break repair via homologous recombination
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1110186

HDAC1
Histone deacetylase 1

8

20

Small-scale

0.966

High

1133046

CHD4
Chromodomain-helicase-DNA-binding protein 4

7

20

Small-scale

0.956

High

1368204

HDAC2
Histone deacetylase 2

4

20

Small-scale

0.895

High

317037

MTA2
Metastasis-associated protein MTA2

3

20

Small-scale

0.847

High

711846

KDM5A
Lysine-specific demethylase 5A

3

7

Small-scale

0.847

High

1102687

MTA1
Metastasis-associated protein MTA1

3

20

Small-scale

0.847

High

1413363

MTA3
Metastasis-associated protein MTA3

3

20

Small-scale

0.827

High

998938

H31
Histone H3.1

2

20

Small-scale

0.806

High

1141359

BRD3
Bromodomain-containing protein 3

2

20

High-throughput

0.776

High

260605

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.754

High

277850

H2AY
Core histone macro-H2A.1

2

20

High-throughput

0.754

High

419269

H2A1B
Histone H2A type 1-B/E

2

20

Small-scale

0.754

High

833793

KDM5C
Lysine-specific demethylase 5C

2

7

High-throughput

0.754

High

1088616

CHD3
Chromodomain-helicase-DNA-binding protein 3

2

20

High-throughput

0.754

High

1384477

PF21A
PHD finger protein 21A

2

18

High-throughput

0.754

High

625701

CSK22
Casein kinase II subunit alpha'

8

14

High-throughput

0.752

High

1453897

H2AW
Core histone macro-H2A.2

2

20

High-throughput

0.737

High

1430553

TSYL1
Testis-specific Y-encoded-like protein 1

5

4

High-throughput

0.722

High

1295327

P66A
Transcriptional repressor p66-alpha

5

7

Small-scale

0.718

High

980532

H4
Histone H4

5

20

Small-scale

0.717

High

1160795

DREB
Drebrin

1

2

Small-scale

0.716

High

998104

CSK21
Casein kinase II subunit alpha

4

13

High-throughput

0.699

High

1163285

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1461752

RBM8A
RNA-binding protein 8A

1

3

High-throughput

0.691

High

1323550

ZN687
Zinc finger protein 687

4

6

Small-scale

0.686

High

352267

MBD3
Methyl-CpG-binding domain protein 3

4

5

Small-scale

0.683

High

1328696

KCD17
BTB/POZ domain-containing protein KCTD17

3

1

High-throughput

0.667

High

1454809

RERE
Arginine-glutamic acid dipeptide repeats protein

1

20

High-throughput

0.656

High

1431855

TSYL2
Testis-specific Y-encoded-like protein 2

3

6

High-throughput

0.656

High

1461131

RCOR1
REST corepressor 1

3

20

High-throughput

0.656

High

995344

CSK2B
Casein kinase II subunit beta

3

3

High-throughput

0.650

High

1159049

RBBP7
Histone-binding protein RBBP7

3

20

Small-scale

0.640

High

227704

SPOP
Speckle-type POZ protein

3

7

Small-scale

0.639

High

397204

ESR1
Estrogen receptor

3

20

High-throughput

0.633

High

1241060

L2GL2
LLGL scribble cell polarity complex component 2

2

6

High-throughput

0.628

High

1437016

ZN408
Zinc finger protein 408

2

9

High-throughput

0.628

High

214974

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

6

Small-scale

0.618

High

274400

SIN3B
Paired amphipathic helix protein Sin3b

1

9

Small-scale

0.618

High

502174

H2AZ
Histone H2A.Z

1

20

Small-scale

0.618

High

591886

H2AX
Histone H2AX

1

20

High-throughput

0.618

High

620648

NUCL
Nucleolin

1

5

Small-scale

0.618

High

674375

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.618

High

755025

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.618

High

794664

RBMX
RNA-binding motif protein, X chromosome

1

5

Small-scale

0.618

High

903517

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

Small-scale

0.618

High

910730

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

8

Small-scale

0.618

High

936682

BRPF1
Peregrin

1

19

High-throughput

0.618

High

981176

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

1097628

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.618

High

1100530

TIF1B
Transcription intermediary factor 1-beta

1

20

High-throughput

0.618

High

1148489

SAFB1
Scaffold attachment factor B1

1

4

Small-scale

0.618

High

1193284

LONF3
LON peptidase N-terminal domain and RING finger protein 3

1

8

High-throughput

0.618

High

1351294

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

20

High-throughput

0.618

High

855540

ATRX
Transcriptional regulator ATRX

2

20

Small-scale

0.614

High

1310144

MGAP
MAX gene-associated protein

2

4

High-throughput

0.611

High

1365474

ZN592
Zinc finger protein 592

2

5

High-throughput

0.611

High

1458215

MBD2
Methyl-CpG-binding domain protein 2

2

5

High-throughput

0.611

High

1278593

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

3

1

High-throughput

0.604

High

1403183

INT14
Integrator complex subunit 14

2

0

High-throughput

0.585

High

129546

MEN1
Menin

2

7

High-throughput

0.584

High

155369

CDKA1
Cyclin-dependent kinase 2-associated protein 1

2

2

High-throughput

0.584

High

221892

CHM2A
Charged multivesicular body protein 2a

2

1

High-throughput

0.584

High

247027

KDM1A
Lysine-specific histone demethylase 1A

2

11

Small-scale

0.584

High

520446

ANDR
Androgen receptor

2

20

High-throughput

0.584

High

982872

RS24
Small ribosomal subunit protein eS24

2

1

Small-scale

0.584

High

1066547

RBBP4
Histone-binding protein RBBP4

2

18

Small-scale

0.584

High

1428582

DDX24
ATP-dependent RNA helicase DDX24

2

6

High-throughput

0.584

High

411113

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

5

High-throughput

0.576

High

95908

E7EQY4
Metastasis-associated protein MTA3

1

20

High-throughput

0.575

High

1450751

ASF1B
Histone chaperone ASF1B

1

7

High-throughput

0.575

High

334594

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

17

High-throughput

0.541

High

900553

FXR2
RNA-binding protein FXR2

1

5

High-throughput

0.541

High

944170

WDR4
tRNA

1

20

High-throughput

0.541

High

1057038

FMR1
Fragile X messenger ribonucleoprotein 1

1

5

High-throughput

0.541

High

1383512

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

2

High-throughput

0.541

High

376090

RASK
GTPase KRas

1

2

High-throughput

0.536

High

542280

TOP1
DNA topoisomerase 1

1

4

High-throughput

0.536

High

682655

S100P
Protein S100-P

1

5

High-throughput

0.536

High

832833

BCL6
B-cell lymphoma 6 protein

1

10

Small-scale

0.536

High

872880

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.536

High

960939

RL15
Large ribosomal subunit protein eL15

1

3

High-throughput

0.536

High

1047780

NOTC2
Neurogenic locus notch homolog protein 2

1

13

High-throughput

0.536

High

1065489

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

1116128

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

13

High-throughput

0.536

High

1311300

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

2

High-throughput

0.536

High

1348992

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.536

High

1361038

P66B
Transcriptional repressor p66-beta

1

7

High-throughput

0.536

High

1438916

ZN532
Zinc finger protein 532

1

5

High-throughput

0.536

High

1453809

FOXJ2
Forkhead box protein J2

1

10

High-throughput

0.536

High

1232638

Q6FHY5
MEOX2 protein

1

8

High-throughput

0.515

High

1216420

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

1259702

RS27L
Ribosomal protein eS27-like

1

0

High-throughput

0.513

High

1434467

ESF1
ESF1 homolog

1

0

High-throughput

0.513

High

1445883

ZCC17
Zinc finger CCHC domain-containing protein 17

1

0

High-throughput

0.513

High

336143

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

6

High-throughput

0.508

High

885923

KC1E
Casein kinase I isoform epsilon

1

7

High-throughput

0.508

High

928363

ATN1
Atrophin-1

1

20

High-throughput

0.508

High

1371769

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

13

High-throughput

0.508

High

436756

KPCB
Protein kinase C beta type

1

5

Small-scale

0.501

High

964509

SUMO2
Small ubiquitin-related modifier 2

1

8

High-throughput

0.501

High

423859

APOD
Apolipoprotein D

1

0

High-throughput

0.493

High

718484

CD6
T-cell differentiation antigen CD6

1

2

High-throughput

0.489

High

1199959

P5CR3
Pyrroline-5-carboxylate reductase 3

1

1

High-throughput

0.489

High

894245

MEOX2
Homeobox protein MOX-2

1

8

High-throughput

0.481

High

1461753

FHOD1
FH1/FH2 domain-containing protein 1

1

2

Small-scale

0.481

High

71485

P20L1
PHD finger protein 20-like protein 1

1

4

Small-scale

0.479

High

138784

IMA4
Importin subunit alpha-4

1

12

High-throughput

0.479

High

157976

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

191156

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

13

High-throughput

0.479

High

282801

E2F6
Transcription factor E2F6

1

9

Small-scale

0.479

High

292882

GRAP2
GRB2-related adapter protein 2

1

7

High-throughput

0.479

High

299496

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

2

Small-scale

0.479

High

373473

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

406789

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

447572

NPM
Nucleophosmin

1

5

High-throughput

0.479

High

558489

XRCC6
X-ray repair cross-complementing protein 6

1

15

High-throughput

0.479

High

675724

TYY1
Transcriptional repressor protein YY1

1

20

High-throughput

0.479

High

723142

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

Small-scale

0.479

High

879609

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

20

High-throughput

0.479

High

887325

CEBPA
CCAAT/enhancer-binding protein alpha

1

14

High-throughput

0.479

High

905285

MECP2
Methyl-CpG-binding protein 2

1

14

High-throughput

0.479

High

960022

RS3A
Small ribosomal subunit protein eS1

1

3

Small-scale

0.479

High

986811

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

8

High-throughput

0.479

High

1024232

TFAM
Transcription factor A, mitochondrial

1

19

High-throughput

0.479

High

1045900

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

1062712

DHX9
ATP-dependent RNA helicase A

1

9

Small-scale

0.479

High

1157991

DDB1
DNA damage-binding protein 1

1

6

Small-scale

0.479

High

1247645

SAMD1
Sterile alpha motif domain-containing protein 1

1

12

Small-scale

0.479

High

1256071

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1276958

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

12

High-throughput

0.479

High

1278985

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

12

Small-scale

0.479

High

1289715

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1290002

LUZP1
Leucine zipper protein 1

1

16

High-throughput

0.479

High

1311663

KIBRA
Protein KIBRA

1

10

High-throughput

0.479

High

1313525

SMC5
Structural maintenance of chromosomes protein 5

1

18

High-throughput

0.479

High

1315928

RCOR2
REST corepressor 2

1

20

High-throughput

0.479

High

1329007

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

15

High-throughput

0.479

High

1332997

MLKL
Mixed lineage kinase domain-like protein

1

3

High-throughput

0.479

High

1339034

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1352829

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

1357173

GATD1
GATA zinc finger domain-containing protein 1

1

1

Small-scale

0.479

High

1361984

ARAP2
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

1

1

High-throughput

0.479

High

1367572

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1368016

RREB1
Ras-responsive element-binding protein 1

1

10

High-throughput

0.479

High

1380249

FBXW7
F-box/WD repeat-containing protein 7

1

9

Small-scale

0.479

High

1396150

Z512B
Zinc finger protein 512B

1

15

High-throughput

0.479

High

1401444

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1407736

EBP2
Probable rRNA-processing protein EBP2

1

1

High-throughput

0.479

High

1421348

BC11B
B-cell lymphoma/leukemia 11B

1

11

High-throughput

0.479

High

1430035

NSRP1
Nuclear speckle splicing regulatory protein 1

1

3

High-throughput

0.479

High

1430828

BC11A
BCL11 transcription factor A

1

11

High-throughput

0.479

High

1436823

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.479

High

1439724

JPH1
Junctophilin-1

1

1

High-throughput

0.479

High

1445911

HM20A
High mobility group protein 20A

1

20

High-throughput

0.479

High

1447542

PRDM5
PR domain zinc finger protein 5

1

8

High-throughput

0.479

High

1452477

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

8

High-throughput

0.479

High

1453044

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.479

High

1454093

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

20

High-throughput

0.479

High

1454669

RCOR3
REST corepressor 3

1

20

High-throughput

0.479

High

1454771

HECW2
E3 ubiquitin-protein ligase HECW2

1

7

High-throughput

0.479

High

1454897

ZN219
Zinc finger protein 219

1

11

High-throughput

0.479

High

1459291

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1459977

SMBT1
Scm-like with four MBT domains protein 1

1

6

Small-scale

0.479

High

1461340

INT6
Integrator complex subunit 6

1

1

High-throughput

0.479

High

1461749

SNX6
Sorting nexin-6

1

2

High-throughput

0.479

High

1461751

ZN330
Zinc finger protein 330

1

8

High-throughput

0.479

High

770327

RL22
Large ribosomal subunit protein eL22

1

0

Small-scale

0.458

High

1008524

ARGI2
Arginase-2, mitochondrial

1

0

High-throughput

0.458

High

1229214

INT3
Integrator complex subunit 3

1

0

High-throughput

0.458

High

1243340

INT5
Integrator complex subunit 5

1

0

High-throughput

0.458

High

1243384

LRC8B
Volume-regulated anion channel subunit LRRC8B

1

0

High-throughput

0.458

High

1323858

INT1
Integrator complex subunit 1

1

0

High-throughput

0.458

High

1338430

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1339570

NEUA
N-acylneuraminate cytidylyltransferase

1

0

High-throughput

0.458

High

1357658

NSE1
Non-structural maintenance of chromosomes element 1 homolog

1

0

High-throughput

0.458

High

1361543

CTBL1
Beta-catenin-like protein 1

1

0

High-throughput

0.458

High

1398218

CBPC4
Cytosolic carboxypeptidase 4

1

0

High-throughput

0.458

High

1411522

PDD2L
Programmed cell death protein 2-like

1

0

High-throughput

0.458

High

1450707

INT13
Integrator complex subunit 13

1

0

High-throughput

0.458

High

1450779

INT10
Integrator complex subunit 10

1

0

High-throughput

0.458

High

844085

HD
Huntingtin

1

2

High-throughput

0.457

High

1150847

SF01
Splicing factor 1

1

3

High-throughput

0.457

High

616044

RL17
Large ribosomal subunit protein uL22

1

3

High-throughput

0.445

High

658470

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.445

High

809912

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.445

High

861014

RS10
Small ribosomal subunit protein eS10

1

3

High-throughput

0.445

High

877258

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.445

High

993020

RACK1
Small ribosomal subunit protein RACK1

1

16

High-throughput

0.445

High

1034629

AK17A
A-kinase anchor protein 17A

1

2

High-throughput

0.445

High

1315265

CA174
UPF0688 protein C1orf174

1

2

High-throughput

0.445

High

1411908

UTP23
rRNA-processing protein UTP23 homolog

1

1

High-throughput

0.445

High

1461748

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.445

High

250168

ADCY9
Adenylate cyclase type 9

1

1

High-throughput

0.437

High

829592

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

2

Small-scale

0.437

High

1027972

ECT2L
Epithelial cell-transforming sequence 2 oncogene-like

1

3

High-throughput

0.437

High

1130680

GSE1
Genetic suppressor element 1

1

5

High-throughput

0.437

High

1351350

BPIB1
BPI fold-containing family B member 1

1

1

High-throughput

0.437

High

1361192

DYH7
Dynein axonemal heavy chain 7

1

2

Small-scale

0.437

High

1421088

TANC1
Protein TANC1

1

7

High-throughput

0.437

High

1452539

DYH9
Dynein axonemal heavy chain 9

1

2

Small-scale

0.437

High

1461750

T3JAM
TRAF3-interacting JNK-activating modulator

1

7

High-throughput

0.437

High

108089

G3V529
ATP-dependent RNA helicase

1

7

High-throughput

0.407

High

1157423

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

High-throughput

0.279

Low

1461747

CAPS1
Calcium-dependent secretion activator 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025