HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ADRM1 (Q16186)
Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)
Gene: ADRM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.894

Property	Details
Experiments	25666615, 35987950, 35256949, 23503661
Identification Methods	two hybrid, x-ray crystallography, pull down, proximity labelling technology, affinity chromatography technology
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	Proteasom_Rpn13~ubiquitin, RPN13_C~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 407
+	Hs
		475039 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		ADRM1_HUMAN (1-407): 8.77e-165: 470: 100.00
+	Hs
		475821 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ADRM1_HUMAN (1-407): 8.77e-165: 470: 100.00