Protein: RING2
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)

Gene: RING2, Rnf2
Organism: Mus musculus
Interactions: 134
UniProt ID: Q9CQJ4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000151 - ubiquitin ligase complex
GO:0000278 - mitotic cell cycle
GO:0000791 - euchromatin
GO:0000792 - heterochromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

639478

BMI1
Polycomb complex protein BMI-1

8

19

Small-scale

0.975

High

1208123

RYBP
RING1 and YY1-binding protein

7

20

Small-scale

0.958

High

620793

PCGF2
Polycomb group RING finger protein 2

6

19

Small-scale

0.953

High

193415

RING1
E3 ubiquitin-protein ligase RING1

4

20

Small-scale

0.892

High

1321732

RING2
E3 ubiquitin-protein ligase RING2

4

20

Small-scale

0.890

High

1257537

CBX7
Chromobox protein homolog 7

3

20

Small-scale

0.867

High

1208443

BCOR
BCL-6 corepressor

2

20

Small-scale

0.802

High

1321744

CBX8
Chromobox protein homolog 8

2

20

Small-scale

0.802

High

1246747

PCGF1
Polycomb group RING finger protein 1

2

19

Small-scale

0.789

High

1307909

PCGF6
Polycomb group RING finger protein 6

2

20

Small-scale

0.789

High

1321743

PHC2
Polyhomeotic-like protein 2

7

20

Small-scale

0.745

High

1144863

PHC1
Polyhomeotic-like protein 1

7

20

Small-scale

0.742

High

223231

CBX4
E3 SUMO-protein ligase CBX4

1

20

Small-scale

0.691

High

675501

CBX2
Chromobox protein homolog 2

1

20

Small-scale

0.691

High

1112809

PCGF5
Polycomb group RING finger protein 5

1

19

Small-scale

0.691

High

1207257

PCGF3
Polycomb group RING finger protein 3

1

19

Small-scale

0.691

High

1307837

YAF2
YY1-associated factor 2

1

20

Small-scale

0.691

High

1158239

KDM2B
Lysine-specific demethylase 2B

3

20

Small-scale

0.674

High

1169776

KDM1A
Lysine-specific histone demethylase 1A

3

6

Small-scale

0.662

High

1225135

SCMH1
Polycomb protein SCMH1

3

20

Small-scale

0.660

High

886509

LMBL2
Lethal(3)malignant brain tumor-like protein 2

3

20

Small-scale

0.656

High

1321737

CBX6
Chromobox protein homolog 6

1

20

Small-scale

0.618

High

57636

MGAP
MAX gene-associated protein

2

12

Small-scale

0.611

High

590496

PO5F1
POU domain, class 5, transcription factor 1

2

13

High-throughput

0.611

High

903677

WDR5
WD repeat-containing protein 5

2

16

Small-scale

0.611

High

936425

HDAC2
Histone deacetylase 2

2

15

Small-scale

0.584

High

1141316

CSK21
Casein kinase II subunit alpha

2

20

Small-scale

0.584

High

1194680

NANOG
Homeobox protein NANOG

2

20

High-throughput

0.584

High

1207412

RBBP5
Retinoblastoma-binding protein 5

2

14

Small-scale

0.584

High

1164651

Q6TKP2
Neuronal pentraxin with chromo domain

1

20

Small-scale

0.575

High

57329

AF9
Protein AF-9

1

12

Small-scale

0.561

High

1321746

SKP1
S-phase kinase-associated protein 1

1

12

Small-scale

0.554

High

659355

MAX
Protein max

2

19

Small-scale

0.552

High

1161099

Q6PED7
Auts2 protein

2

20

Small-scale

0.549

High

222427

CSK22
Casein kinase II subunit alpha'

1

20

Small-scale

0.536

High

650039

XRCC5
X-ray repair cross-complementing protein 5

1

5

Small-scale

0.536

High

926158

HSP7C
Heat shock cognate 71 kDa protein

1

8

Small-scale

0.536

High

931975

CSK2B
Casein kinase II subunit beta

1

10

Small-scale

0.536

High

996146

TFDP1
Transcription factor Dp-1

1

5

Small-scale

0.536

High

1113107

TF2L1
Transcription factor CP2-like protein 1

1

7

High-throughput

0.536

High

1125432

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

8

Small-scale

0.536

High

1137349

THOC6
THO complex subunit 6 homolog

1

20

Small-scale

0.536

High

1141950

RBBP4
Histone-binding protein RBBP4

1

15

Small-scale

0.536

High

1141971

RBBP7
Histone-binding protein RBBP7

1

16

Small-scale

0.536

High

1142258

Q61177
Casein kinase II subunit alpha

1

20

Small-scale

0.536

High

1149466

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

20

Small-scale

0.536

High

1206589

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

17

Small-scale

0.536

High

1206929

KAISO
Transcriptional regulator Kaiso

1

20

Small-scale

0.536

High

1208513

PHC3
Polyhomeotic-like protein 3

1

20

Small-scale

0.536

High

1225034

CDC73
Parafibromin

1

1

Small-scale

0.536

High

1225191

MATR3
Matrin-3

1

14

Small-scale

0.536

High

1225269

MTA1
Metastasis-associated protein MTA1

1

8

Small-scale

0.536

High

1265292

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

Small-scale

0.536

High

1160394

SPA24
Spermatogenesis-associated protein 24

1

1

Small-scale

0.501

High

397

AUTS2
Autism susceptibility gene 2 protein homolog

1

20

Small-scale

0.500

High

57038

MED14
Mediator of RNA polymerase II transcription subunit 14

1

14

Small-scale

0.479

High

93700

E9Q7C1
Mediator of RNA polymerase II transcription subunit 15

1

16

Small-scale

0.479

High

93820

E9QLK7
Transformation/transcription domain-associated protein

1

10

Small-scale

0.479

High

103643

G5E8N3
SET domain, bifurcated 1

1

7

Small-scale

0.479

High

222619

E2F6
Transcription factor E2F6

1

17

Small-scale

0.479

High

250438

AURKB
Aurora kinase B

1

11

Small-scale

0.479

High

251040

KDM6A
Lysine-specific demethylase 6A

1

16

Small-scale

0.479

High

606356

ZFP42
Zinc finger protein 42

1

20

Small-scale

0.479

High

817493

RFX1
MHC class II regulatory factor RFX1

1

6

Small-scale

0.479

High

818761

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.479

High

824692

MAPK2
MAP kinase-activated protein kinase 2

1

4

Small-scale

0.479

High

881368

CTBP2
C-terminal-binding protein 2

1

9

Small-scale

0.479

High

892212

ACTB
Actin, cytoplasmic 1

1

18

Small-scale

0.479

High

892294

MO4L1
Mortality factor 4-like protein 1

1

2

Small-scale

0.479

High

903076

DCAF7
DDB1- and CUL4-associated factor 7

1

20

Small-scale

0.479

High

929807

ACTG
Actin, cytoplasmic 2

1

16

Small-scale

0.479

High

930652

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

5

Small-scale

0.479

High

993237

PEBB
Core-binding factor subunit beta

1

2

Small-scale

0.479

High

994733

GATA4
Transcription factor GATA-4

1

18

Small-scale

0.479

High

1111842

HP1B3
Heterochromatin protein 1-binding protein 3

1

3

Small-scale

0.479

High

1113386

RNPC3
RNA-binding region-containing protein 3

1

8

Small-scale

0.479

High

1142416

PLSL
Plastin-2

1

15

Small-scale

0.479

High

1142718

ERR2
Steroid hormone receptor ERR2

1

17

Small-scale

0.479

High

1143970

CCNC
Cyclin-C

1

6

Small-scale

0.479

High

1157873

PAXI1
PAX-interacting protein 1

1

12

Small-scale

0.479

High

1160052

MBTD1
MBT domain-containing protein 1

1

20

Small-scale

0.479

High

1169607

PF21A
PHD finger protein 21A

1

20

Small-scale

0.479

High

1186660

MBB1A
Myb-binding protein 1A

1

3

Small-scale

0.479

High

1186785

SGO2
Shugoshin 2

1

1

Small-scale

0.479

High

1194388

NPM2
Nucleoplasmin-2

1

4

Small-scale

0.479

High

1194504

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

Small-scale

0.479

High

1206351

ACTBL
Beta-actin-like protein 2

1

16

Small-scale

0.479

High

1206886

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

20

Small-scale

0.479

High

1207138

Q8BQ46
TAF15 RNA polymerase II, TATA box binding protein

1

19

Small-scale

0.479

High

1207265

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

8

Small-scale

0.479

High

1207428

SALL4
Sal-like protein 4

1

6

Small-scale

0.479

High

1207468

Q8BYC8
Scm polycomb group protein-like 2

1

20

Small-scale

0.479

High

1207568

EPC2
Enhancer of polycomb homolog 2

1

3

Small-scale

0.479

High

1208074

EPC1
Enhancer of polycomb homolog 1

1

3

Small-scale

0.479

High

1208458

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

12

Small-scale

0.479

High

1208487

EP400
E1A-binding protein p400

1

20

Small-scale

0.479

High

1246861

BRD8
Bromodomain-containing protein 8

1

18

Small-scale

0.479

High

1257418

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

Small-scale

0.479

High

1265162

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

18

Small-scale

0.479

High

1265453

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

1321733

CENPV
Centromere protein V

1

1

Small-scale

0.479

High

1321735

PHF14
PHD finger protein 14

1

7

Small-scale

0.479

High

1321738

HM20A
High mobility group protein 20A

1

18

Small-scale

0.479

High

1321739

Q9DCC5
Cbx3 protein

1

20

Small-scale

0.479

High

1321740

Q9ERL0
Btk-PH-domain binding protein

1

12

Small-scale

0.479

High

1321741

PALLD
Palladin

1

12

Small-scale

0.479

High

1321742

DMAP1
DNA methyltransferase 1-associated protein 1

1

3

Small-scale

0.479

High

1321745

RUVB2
RuvB-like 2

1

5

Small-scale

0.479

High

1321747

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

4

Small-scale

0.479

High

1321748

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

20

Small-scale

0.479

High

1321749

ACL6A
Actin-like protein 6A

1

17

Small-scale

0.479

High

1307793

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

Small-scale

0.458

High

1307815

PGR1A
PAXIP1-associated glutamate-rich protein 1A

1

0

Small-scale

0.458

High

1321698

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.458

High

1321736

MRGBP
MRG/MORF4L-binding protein

1

0

Small-scale

0.458

High

292509

SETB1
Histone-lysine N-methyltransferase SETDB1

1

7

Small-scale

0.445

High

613033

CBX3
Chromobox protein homolog 3

1

20

Small-scale

0.445

High

1186799

MCAF1
Activating transcription factor 7-interacting protein 1

1

13

Small-scale

0.445

High

1194979

Q80ZU1
WD repeat domain 68

1

20

Small-scale

0.445

High

1207287

TOX4
TOX high mobility group box family member 4

1

20

Small-scale

0.445

High

1208638

Q8CJ76
Leukemia-associated protein MLLT1

1

13

Small-scale

0.445

High

1265262

Q91YZ2
C-terminal binding protein 2

1

9

Small-scale

0.445

High

99865

F6M2J9
Nuclear receptor coactivator-6 beta

1

14

Small-scale

0.437

High

1112975

Q3UM65
Runt-related transcription factor

1

6

Small-scale

0.437

High

1118851

WDR18
WD repeat-containing protein 18

1

18

Small-scale

0.437

High

1143157

PZP
Pregnancy zone protein

1

2

Small-scale

0.437

High

1208028

Q8C839
Splicing factor 3B subunit 1

1

3

Small-scale

0.437

High

1257589

RBM39
RNA-binding protein 39

1

20

Small-scale

0.437

High

1265113

POTE1
Protection of telomeres protein 1

1

1

Small-scale

0.437

High

1321734

ZN687
Zinc finger protein 687

1

8

Small-scale

0.437

High

1257625

Q8VHT4
E2F6b

1

17

Small-scale

0.407

High

1265854

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

3

Small-scale

0.407

High

93388

E9Q284
Coilin

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024