HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RAPH1 (Q70E73)
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)
Gene: RAPH1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1250
+	Hs
		475019 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95
+	Hs
		475709 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (700-1248): 2.61e-15: 84.1: 10.87
+	Hs
		227460 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MDC1_HUMAN (718-1249): 2.96e-14: 80.3: 14.37
+	Hs
		228210 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TITIN_HUMAN (586-1241): 1.11e-11: 71.9: 13.92
+	Hs
		227838 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SRCAP_HUMAN (502-1060): 1.36e-11: 71.8: 11.70
+	Hs
		228101 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KMT2C_HUMAN (816-1249): 7.69e-10: 66: 11.79
+	Mm
		88466 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		D3Z656_MOUSE (503-893): 4.52e-10: 66.4: 12.59
+	Hs
		475943 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OTOG_HUMAN (874-1247): 1.88e-18: 94.1: 10.94
+	At
		1092118 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9LIE8_ARATH (817-1249): 4.65e-15: 83: 16.17