HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TAXB1 (Q86VP1)
Tax1-binding protein 1 (TRAF6-binding protein)
Gene: TAX1BP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31723608, 23503661
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Zn-C2H2_12~ubiquitin
Common GO terms	GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0019900 - kinase binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 789
+	Hs
		227332 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00
+	Hs
		148181 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CTRO_HUMAN (96-665): 2.04e-20: 99.2: 11.44
+	Hs
		227434 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DCTN1_HUMAN (173-498): 9.09e-17: 87.3: 18.71
+	Hs
		226691 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH11_HUMAN (315-745): 1.27e-16: 87: 10.96
+	Hs
		226680 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH10_HUMAN (290-756): 5.81e-16: 84.7: 10.02
+	Hs
		475085 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		TAXB1_HUMAN (1-789): 5.15e-85: 288: 100.00
+	Hs
		226679 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MYH9_HUMAN (412-783): 9.06e-12: 71.2: 9.68
+	Hs
		228609 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UACA_HUMAN (145-584): 3.36e-09: 62.6: 17.62
+	Hs
		476001 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TAXB1_HUMAN (1-789): 5.15e-85: 288: 100.00
+	Hs
		1025545 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00
+	Hs
		1219401 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		MYO5A_HUMAN (269-660): 1.32e-13: 77.3: 14.15
+	Hs
		1025420 Q5U5U6_HUMAN (1-234): 1.14e-59: 197: 17.92		CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00
+	Hs
		475014 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00
+	Hs
		1025496 Q96C32_HUMAN (1-153): 4.21e-49: 172: 19.48		CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00
+	Hs
		475695 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00
+	Hs
		475291 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MYH1_HUMAN (181-778): 1.83e-23: 109: 9.33
+	Hs
		475417 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MYH9_HUMAN (412-783): 9.06e-12: 71.2: 9.68