Protein: MYO5
Myosin-5 (Actin-dependent myosin-I MYO5) (Class I unconventional myosin MYO5) (Type I myosin MYO5)

Gene: MYO5
Organism: Saccharomyces cerevisiae S288C
Interactions: 137
UniProt ID: Q04439

Gene Ontology (top 5):
GO:0000146 - microfilament motor activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0005933 - cellular bud

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

449178

CALM
Calmodulin

8

19

Small-scale

0.977

High

864747

BBC1
Myosin tail region-interacting protein MTI1

5

9

Small-scale

0.944

High

1046655

OSH2
Oxysterol-binding protein homolog 2

5

3

Small-scale

0.939

High

1046637

MYO5
Myosin-5

5

17

Small-scale

0.934

High

814271

RV167
Reduced viability upon starvation protein 167

5

11

Small-scale

0.925

High

736134

ARP2
Actin-related protein 2

4

17

Small-scale

0.891

High

779019

MYO3
Myosin-3

3

20

High-throughput

0.868

High

805434

BZZ1
Protein BZZ1

3

2

High-throughput

0.867

High

916896

YGZ2
Ankyrin repeat-containing protein YGL242C

3

14

High-throughput

0.856

High

865586

ARP3
Actin-related protein 3

3

19

Small-scale

0.849

High

948648

ACT
Actin

2

14

Small-scale

0.821

High

874262

CLA4
Serine/threonine-protein kinase CLA4

2

20

High-throughput

0.807

High

744921

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

2

5

High-throughput

0.793

High

790588

VRP1
Verprolin

12

6

Small-scale

0.763

High

1046654

LAS17
Proline-rich protein LAS17

9

5

Small-scale

0.757

High

798163

ARPC1
Actin-related protein 2/3 complex subunit 1

5

16

Small-scale

0.715

High

587334

ABP1
Actin-binding protein

2

12

Small-scale

0.712

High

745037

YSC84
Protein YSC84

1

9

High-throughput

0.698

High

850477

LSB3
LAS seventeen-binding protein 3

1

17

High-throughput

0.698

High

750342

ARPC4
Actin-related protein 2/3 complex subunit 4

4

2

Small-scale

0.680

High

824667

BNR1
BNI1-related protein 1

3

6

High-throughput

0.674

High

1030252

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

3

13

High-throughput

0.674

High

824700

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

13

High-throughput

0.671

High

903549

SHE4
SWI5-dependent HO expression protein 4

3

1

Small-scale

0.670

High

1024984

2ABA
Protein phosphatase PP2A regulatory subunit B

3

1

High-throughput

0.666

High

825849

ARPC5
Actin-related protein 2/3 complex subunit 5

3

4

Small-scale

0.658

High

1046640

ARPC3
Actin-related protein 2/3 complex subunit 3

3

4

Small-scale

0.658

High

525088

HSP71
Heat shock protein SSA1

3

8

High-throughput

0.656

High

803377

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

7

High-throughput

0.625

High

527628

HSP72
Heat shock protein SSA2

3

8

High-throughput

0.624

High

818140

SHO1
High osmolarity signaling protein SHO1

1

0

High-throughput

0.622

High

623945

MYO2
Myosin-2

1

20

Small-scale

0.621

High

1046644

SRL1
Cell wall protein SRL1

2

1

High-throughput

0.620

High

1042314

PKH3
Serine/threonine-protein kinase PKH3

2

16

High-throughput

0.619

High

817242

ZRG8
Zinc-regulated protein 8

2

1

High-throughput

0.602

High

826431

AIM21
Altered inheritance of mitochondria protein 21

2

3

High-throughput

0.602

High

1046657

SKM1
Serine/threonine-protein kinase SKM1

1

20

High-throughput

0.590

High

924924

APP1
Phosphatidate phosphatase APP1

2

1

High-throughput

0.586

High

922982

ARPC2
Actin-related protein 2/3 complex subunit 2

2

2

Small-scale

0.584

High

815773

SAP1
Protein SAP1

1

5

High-throughput

0.578

High

739093

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

1

6

Small-scale

0.573

High

546204

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.571

High

802803

OSH3
Oxysterol-binding protein homolog 3

1

3

Small-scale

0.552

High

1042993

STE20
Serine/threonine-protein kinase STE20

1

20

High-throughput

0.552

High

1046645

YO389
Uncharacterized protein YOR389W

2

3

High-throughput

0.550

High

642464

MCK1
Protein kinase MCK1

1

16

High-throughput

0.541

High

678127

SYP1
Suppressor of yeast profilin deletion

1

8

High-throughput

0.541

High

728716

ACBP
Acyl-CoA-binding protein

1

1

High-throughput

0.541

High

779882

MID2
Cell wall integrity sensor MID2

1

4

High-throughput

0.541

High

893034

HSV2
SVP1-like protein 2

1

4

High-throughput

0.541

High

917061

MCM6
DNA replication licensing factor MCM6

1

7

High-throughput

0.541

High

932298

ZDS2
Protein ZDS2

1

3

High-throughput

0.541

High

1028028

ACAC
Acetyl-CoA carboxylase

1

1

High-throughput

0.541

High

1038793

STD1
Protein STD1

1

3

High-throughput

0.541

High

1040690

MET31
Transcriptional regulator MET31

1

1

High-throughput

0.541

High

1046639

CYK2
Cytokinesis protein 2

1

4

High-throughput

0.541

High

1046650

HER1
HMG2-induced ER-remodeling protein 1

1

4

High-throughput

0.541

High

637279

PWP1
Periodic tryptophan protein 1

1

4

High-throughput

0.536

High

713301

MCM5
Minichromosome maintenance protein 5

1

8

High-throughput

0.536

High

617954

YPK2
Serine/threonine-protein kinase YPK2/YKR2

1

7

Small-scale

0.527

High

671098

SIS1
Protein SIS1

2

1

High-throughput

0.521

High

737993

KRE6
Beta-glucan synthesis-associated protein KRE6

1

0

High-throughput

0.518

High

816670

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.518

High

823109

ATG3
Autophagy-related protein 3

1

0

High-throughput

0.518

High

825526

YIJ2
Uncharacterized protein YIL092W

1

0

High-throughput

0.518

High

844400

YG4I
Uncharacterized GTP-binding protein YGR210C

1

0

High-throughput

0.518

High

1046652

SCM3
Protein SCM3

1

0

High-throughput

0.518

High

454485

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

359353

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

High-throughput

0.508

High

836332

BNI1
Protein BNI1

1

6

High-throughput

0.508

High

668953

ERG6
Sterol 24-C-methyltransferase ERG6

1

2

Small-scale

0.504

High

1046656

ERG27
3-keto-steroid reductase ERG27

1

4

Small-scale

0.504

High

751786

PRP8
Pre-mRNA-splicing factor 8

1

2

High-throughput

0.501

High

917096

MDS3
Negative regulator of sporulation MDS3

1

1

High-throughput

0.501

High

1044541

VPS64
Vacuolar protein sorting-associated protein 64

1

1

High-throughput

0.501

High

763720

MTH1
Protein MTH1

1

3

High-throughput

0.494

High

867861

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

2

High-throughput

0.494

High

858065

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.489

High

1042690

PKH1
Serine/threonine-protein kinase PKH1

1

14

Small-scale

0.481

High

1046649

PKH2
Serine/threonine-protein kinase PKH2

1

15

Small-scale

0.481

High

760562

SCD5
Protein SCD5

1

0

High-throughput

0.480

High

917687

LSG1
Large subunit GTPase 1

1

0

High-throughput

0.480

High

1044291

YD132
Uncharacterized protein YDR132C

1

0

High-throughput

0.480

High

1046648

ENG2
Glucan endo-1,3-beta-D-glucosidase 2

1

0

High-throughput

0.480

High

802695

YHI0
Putative proline--tRNA ligase YHR020W

1

3

High-throughput

0.479

High

812636

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

815234

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

818197

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

2

Small-scale

0.479

High

1046641

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

368750

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.464

High

668499

MED19
Mediator of RNA polymerase II transcription subunit 19

1

1

High-throughput

0.464

High

782252

SUMT
Uroporphyrinogen-III C-methyltransferase

1

1

High-throughput

0.464

High

657127

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

748038

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

803682

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

1046647

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

1046658

ATG40
Autophagy-related protein 40

1

0

Small-scale

0.458

High

1046646

YP277
Uncharacterized protein YPL277C

1

3

High-throughput

0.457

High

464636

PBS2
MAP kinase kinase PBS2

1

20

High-throughput

0.457

High

697396

MIG1
Regulatory protein MIG1

1

3

High-throughput

0.457

High

726180

2AAA
Protein phosphatase PP2A regulatory subunit A

1

1

High-throughput

0.457

High

926709

MPS1
Serine/threonine-protein kinase MPS1

1

18

High-throughput

0.457

High

394889

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

742357

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

752709

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

819744

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

836887

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.445

High

645643

AFT1
Iron-regulated transcriptional activator AFT1

1

0

High-throughput

0.438

High

1046638

DYN3
Cytoplasmic dynein intermediate light chain DYN3

1

0

High-throughput

0.438

High

1046643

NBA1
Protein NBA1

1

0

High-throughput

0.438

High

1046659

FYV1
Putative uncharacterized protein FYV1

1

0

High-throughput

0.438

High

708124

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

850198

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

2

High-throughput

0.437

High

918451

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.437

High

922116

COPA
Coatomer subunit alpha

1

3

High-throughput

0.437

High

1046160

PDS5
Sister chromatid cohesion protein PDS5

1

1

High-throughput

0.437

High

453785

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

684839

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

871560

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.426

High

917248

ARI1
NADPH-dependent aldehyde reductase ARI1

1

0

High-throughput

0.426

High

1046651

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

1046653

YDR10
Uncharacterized protein YDR010C

1

1

High-throughput

0.417

High

782556

NU133
Nucleoporin NUP133

1

0

High-throughput

0.282

High

820440

RT106
Histone chaperone RTT106

1

0

High-throughput

0.282

High

923285

MNT4
Probable alpha-1,3-mannosyltransferase MNT4

1

0

High-throughput

0.282

High

797561

MCFS2
Medium-chain fatty acid ethyl ester synthase/esterase 2

1

0

High-throughput

0.279

Low

758354

YKJ7
Uncharacterized protein YKL097C

1

0

High-throughput

0.261

Low

923042

ZRG17
Protein ZRG17

1

0

High-throughput

0.261

Low

1025247

RGM1
Probable transcription repressor protein RGM1

1

0

High-throughput

0.261

Low

746939

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.249

Low

865744

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

1044731

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

368194

THDH
Threonine dehydratase, mitochondrial

1

0

High-throughput

0.238

Low

673223

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.238

Low

1046642

YAP7
AP-1-like transcription factor YAP7

1

0

High-throughput

0.238

Low

776542

NU120
Nucleoporin NUP120

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025