HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: HOME1 (Q86YM7)
Homer protein homolog 1 (Homer-1)
Gene: HOMER1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.682

Property	Details
Experiments	30200940, 11679592, 35509820, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0014069 - postsynaptic density GO:0044877 - protein-containing complex binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 354
+	Hs
		228830 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HOME3_HUMAN (3-354): 3.77e-60: 199: 49.72
+	Hs
		226756 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EPS15_HUMAN (92-321): 5.03e-30: 123: 11.97
+	Hs
		226884 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		VASP_HUMAN (1-146): 3.19e-28: 115: 22.36
+	Hs
		227627 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRDN_HUMAN (158-347): 6.51e-26: 111: 22.28
+	Hs
		228062 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ENAH_HUMAN (1-143): 1.71e-25: 109: 26.53
+	Hs
		227332 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CACO2_HUMAN (116-340): 1.19e-25: 108: 17.70
+	Mm
		788009 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		EPS15_MOUSE (65-332): 1.05e-27: 116: 13.06
+	Hs
		226436 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DESP_HUMAN (95-342): 9.29e-09: 59.3: 12.30
+	Hs
		227694 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FKB15_HUMAN (72-353): 8.97e-09: 59.3: 14.34
+	Hs
		1025545 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		CACO2_HUMAN (116-340): 1.19e-25: 108: 17.70
+	Hs
		1025420 Q5U5U6_HUMAN (1-234): 1.14e-59: 197: 17.92		CACO2_HUMAN (116-340): 1.19e-25: 108: 17.70
+	Hs
		475014 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		CACO2_HUMAN (116-340): 1.19e-25: 108: 17.70
+	Hs
		1025496 Q96C32_HUMAN (1-153): 4.21e-49: 172: 19.48		CACO2_HUMAN (116-340): 1.19e-25: 108: 17.70
+	Hs
		475452 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		EPS15_HUMAN (92-321): 5.03e-30: 123: 11.97
+	Hs
		475695 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CACO2_HUMAN (116-340): 1.19e-25: 108: 17.70
+	Hs
		476502 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		EP15R_HUMAN (65-303): 4.1e-18: 87.8: 11.94
+	Hs
		476091 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DLG5_HUMAN (107-349): 5.1e-10: 63.1: 13.81
+	Hs
		475882 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FKB15_HUMAN (72-353): 8.97e-09: 59.3: 14.34